Unraveling Cell-Cycle Dynamics in Cancer Sandip Kar  Cell Systems  Volume 2, Issue 1, Pages 8-10 (January 2016) DOI: 10.1016/j.cels.2016.01.007 Copyright © 2016 Elsevier Inc. Terms and Conditions

Figure 1 Schematic Representation of Dynamical Features of the All-or-None G1-S Transition (A) The antagonistic relationship between Cdk2:Cyclins and p27Kip1 is essential for a switch-like G1-S transition. The orange line signifies stable steady states and the dash line unstable steady states. (B) Cdk2:CyclinE1, and not Cdk2:CyclinA, is responsible for the timing of the G1-S transition. (C) In the absence of Cdk2:CyclinE1, Cdk2:CyclinA can take over the job of keeping timing of the G1-S transition. (D) Levels of Emi1 protein can control the irreversibility of the G1-S transition. Cell Systems 2016 2, 8-10DOI: (10.1016/j.cels.2016.01.007) Copyright © 2016 Elsevier Inc. Terms and Conditions