A KRABsody for Embryo-Placental Development

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A KRABsody for Embryo-Placental Development Didier Trono Developmental Cell Volume 41, Issue 6, Pages 578-580 (June 2017) DOI: 10.1016/j.devcel.2017.06.005 Copyright © 2017 Elsevier Inc. Terms and Conditions

Figure 1 The Igf2-Controlling KRAB-ZFP Duet in Murine ESCs In the wild-type cellular context, at the maternal allele, CTCF is recruited to the unmethylated Igf2/H19 ICR and blocks Igf2 promoter activation by distal enhancer. At the paternal allele, ZFP57 is recruited at the methylated Igf2/H19 ICR, allowing activation of Igf2 promoters. However, P0 is silenced and P1–P3 are dampened by ZFP568-induced repression. In ZFP568 KO embryonic stem cells (ESCs) at the paternal allele, the P0 promoter is unleashed and P1–P3 are further activated, resulting in increased IGF2 levels. Developmental Cell 2017 41, 578-580DOI: (10.1016/j.devcel.2017.06.005) Copyright © 2017 Elsevier Inc. Terms and Conditions