1 USRF A California non-profit organization

2 USRF What is USRF? URSF is an independent, non-profit organization (501c3) founded in 1992 to further the science of urology. Funding Funding -Gifts -Grants -Contracts Governance Governance -Founder -Board of Directors

3 USRF What is USRF? MISSION STATEMENT: To help advance the understanding of common urologic disorders and, through relationships with innovative leaders in the healthcare industry, to perform important clinical trials.

4 USRF Who are we ? Key to Productivity: 2002 USRF Staff

5 USRF Diplomate, American Board of Urology Diplomate, American Board of Urology Clinical faculty, UCLA Clinical faculty, UCLA Associate editor, Urology Associate editor, Urology Committee member, AUA Committee member, AUA Founder and Medical Director Leonard S. Marks, M.D.

6 USRF L.A. Metropolitan Location Population: 16 Million (2nd largest metropolitan area in U.S.) USRF Offices

7 USRF USRF Offices USRF Saw Palmetto Study: Lead Story in Urology Times

8 USRF USRF Offices Updating the USRF Website

9 USRF Economy Economy Efficiency Efficiency -Large patient base -Established practice USRF offers industry... Mannekin Pis

10 USRF Experience Experience -28 trials -Various aspects of research Dedicated space and personnel Dedicated space and personnel -Well-trained staff -Fully-equipped office USRF offers industry... Mannekin Pis

11 USRF Knowledge of industry Knowledge of industry -Consultancies -Study designs Academic involvement Academic involvement -Presentations -Publications USRF offers industry... Mannekin Pis

12 USRF USRF Focus Areas Prostate Diseases Prostate Diseases -Benign -Malignant Impotency (MED) Impotency (MED) Incontinence Incontinence -Male -Female

13 USRF Recent Industry Sponsors Alza Alza Endocare Endocare Diagnostic Ultrasound Diagnostic Ultrasound Glaxo-Wellcome Glaxo-Wellcome Hybritech Hybritech Merck Merck Nutrilite Nutrilite Pfizer Pfizer Pharmacia & Upjohn Pharmacia & Upjohn Synthelabo Synthelabo

14 USRF Recent Clinical Trials (Phase I - IV)

15 USRF Recent Clinical Trials (Phase I - IV) Devices Devices -Prostate stent -Laser -Vaporizing electrode -Ultrasound PSA Testing PSA Testing

16 USRF Academic Collaborations UCLA UCLA Johns Hopkins Johns Hopkins Mayo Clinic Mayo Clinic

17 USRF Educational Mission Dr. Marks lecturing in Mexico City, January 99

18 USRF USRF on WWW

19 USRF clinical trials 28 clinical trials -BPH -CaP -MED -Incontinence -Urinary Infection USRF History,

20 USRF sponsoring companies 17 sponsoring companies -Large and small -Drug and device -Repeat sponsors USRF History,

21 USRF publications in peer-reviewed journals 18 publications in peer-reviewed journals 30 papers presented at scientific meeting 30 papers presented at scientific meeting USRF History,

22 USRF university projects funded 4 university projects funded -UCLA (residents research fund) -Johns Hopkins (morphometry, MRI) -U. Maryland (apoptosis) -Oregon Health Sciences U. (androgen) USRF History,

23 USRF A California non-profit organization