Activation of Adenylyl Cyclase Reduces TGF-β Profibrotic Response in Osteoarthritic Fibroblast-Like Synoviocytes M. Qadri, R. Ostrom, K.A. Elsaid Osteoarthritis.

Slides:

Advertisements

Similar presentations

Inhaled corticosteroids decrease subepithelial collagen deposition by modulation of the balance between matrix metalloproteinase-9 and tissue inhibitor.

Advertisements

GDF5 reduces MMP13 expression in human chondrocytes via DKK1 mediated canonical Wnt signaling inhibition L. Enochson, J. Stenberg, M. Brittberg, A. Lindahl

Full-thickness cartilage defects repaired by human induced pluripotent stem cells (IPSCS)-derived mesenchymal stem cells and plga scaffolds D. Shi, X.

Cannabinoid WIN-55,212-2 mesylate inhibits interleukin-1β induced matrix metalloproteinase and tissue inhibitor of matrix metalloproteinase expression.

Immunomodulatory effect of mesenchymal stem cells following intra-articular injection in a model of osteoarthritis: a potential role for apoptosis P.

P.M. van der Kraan, E.N. Blaney Davidson, A. Blom, W.B. van den Berg

A. Bhave, M. Mont, M. Chugthai, R. Starr Osteoarthritis and Cartilage

R. Takeuchi, H. Ishikawa, T. Kuniya, A. Nakazawa

K.S. Santangelo Osteoarthritis and Cartilage

S. Gavard Osteoarthritis and Cartilage

In vitro cell surface markers are insufficient to identify in vivo/in situ multipotent synovial mesenchymal stem cells isolated from normal or osteoarthritic.

Prospective economic evaluation of the costs for medications and nutraceuticals in knee osteoarthritis M. Chung, N. Zhao, J.B. Wong, C. Wang Osteoarthritis.

The effects of dynamic viscosity on cartilage mechanics

Osteoarthritis and Cartilage

Decreased proteoglycan degradation in IL-1β-treated cartilage co-cultured with TIMP-3- transduced cells J. Mason, A. Donahue, A. Yoskowitz, D. Richardson

Role of endothelin-1 in endochondral ossification and osteoarthritis

W. Hitzl, M. Sattler, F. Eckstein, S. Cotofana

Automatic cartilage segmentation and measurement for diagnosis of OA using 3D box and Gaussian filters X. Cui, S. Li, M. Yu, H. Kim, K.-S. Kwack, B.-H.

Effects of chondroitin sulfate in the pathophysiology of the osteoarthritic joint: a narrative review J. Martel-Pelletier, S. Kwan Tat, J.-P. Pelletier

Mineralization of meniscal enthesis in osteoarthritic knees

Effect of self assembled peptide-mesenchymal stem cell complex on delaying the progression of osteoarthritis S. Kim, S. Lee, Y. Jung, J. Kim, S. Kim

G. Venne, S. Pang, Y. Tse, R. Ellis Osteoarthritis and Cartilage

The differences on extracellular matrix among each portion of meniscus

Immunomodulatory effect of mesenchymal stem cells following intra-articular injection in a model of osteoarthritis: a potential role for apoptosis P.

Damage to The Extracellular Matrix (ECM) in Articular Cartilage is Observed via Changes in The T2–T2 Exchange Rates Between Fluid in The Pore Space and.

P. Yuan, X. Zhang, W. Yang, W. Kang, B. Yang, J. li, B. Chen, X. Li, B

Efficacy of the selective inducible nitric oxide synthase inhibitor sd-6010 in nonclinical inflammatory, neuropathic, and osteoarthritis pain J.R. Connor,

Vitamin D prevents articular cartilage erosion by regulating collagen II turnover through TGF-β1 in ovariectomized rats S. Li, G. Niu, Y. Wu, G. Du,

P.M. van der Kraan, E.N. Blaney Davidson, A. Blom, W.B. van den Berg

R.R. Yammani, J. Haywood, R.F. Loeser Osteoarthritis and Cartilage

Lack of anti-inflammatory and anti-catabolic effects on basal inflamed osteoarthritic chondrocytes or synoviocytes by adipose stem cell-conditioned medium

B. Vafaeian, S. Adeeb, M. El-Rich, J. Jaremko

Role of TCF4 in signaling crosstalk with NFκB in human chondrocytes

The influence of early osteoarthritic collagen network de-structuring in articular cartilage on the tissue stiffness and swelling properties M. Nickien,

R2−R1ρ as a Potential Biomarker for Tracking Cartilage Matrix Changes in Osteoarthritic Knees after Hyaluronic Acid Injection M. Tanaka, A. Azus, V.

Effectiveness of thermal and athermal short-wave diathermy for the management of knee osteoarthritis: a systematic review and meta-analysis Y. Laufer,

Different responses of healthy, relative healthy and OA chondrocytes with IL1β treatment under hypoxia and normoxia X. Huang, L. Zhong, J. Post, M. Karperien

Y. Levy, A. Hasegawa, S. Patil, M. Lotz, D. D'Lima

M.N. Khan, M.Y. Ansari, T.M. Haqqi Osteoarthritis and Cartilage

Osteoarthritis and Cartilage

M.L. Roemhildt, A.E. Gauthier Osteoarthritis and Cartilage

Emerging role of endothelin receptor type B in regulating chondrogenic and hypertrophic changes of human mesenchymal stem cells M. Au, M. Zhu, W.-J.

Z. Huang, T. Stabler, F. Pei, V. Kraus Osteoarthritis and Cartilage

Acute influences of draw-in maneuver for knee adduction moment and hip and trunk muscle activities during a person's manner of walking S. Ota, H. Ohko,

Increased susceptibility to IL-1 accelerates osteoarthritic change in 3D-cultured chondrocytes and in vivo animal models Y. Takeda, Y. Niki, Y. Fukuhara,

Gene expression analysis of OA synovium reveals elevation of TGF-ß responsive genes in OA-related fibrosis D.F. Remst, A.B. Blom, E.N. Blaney Davidson,

The interaction of lubricin/proteoglycan-4 (PRG4) with toll-like receptor 2: an anti- inflammatory role of PRG4 in synovial fluids from patients with osteoarthritis

A systematic review of the efficacy and general safety of antibodies to NGF in the treatment of OA of the hip or knee T.J. Schnitzer, J.A. Marks Osteoarthritis.

Damps provide a link between joint tissue damage and pain through direct activation of TLR4 expressed by sensory neurons R.E. Miller, P.B. Tran, S. Ishihara,

S. Allaith, P. D. Clegg, E. G. Canty-Laird, S. Tew, B. Caterson, E

Evidence for bone mineral density and bone resorption in middle and elderly women with knee osteoarthritis in Shanghai: a cross sectional study Q. Xiaofeng

Monocyte chemoattractant protein 1 induced chondrocytes degeneration and cartilage degradation in osteoarthritis X. yuankun, K. Yan, W. Bin, L. Jian-Hao

B. Zielinska, M. Killian, M. Kadmiel, M. Nelsen, T.L. Haut Donahue

Leptin signaling and body weight are independent mediators of spontaneous knee osteoarthritis in female rats J. Hudson, M. West, Y. Fu, T. Griffin Osteoarthritis.

Location-specific hip joint space width for progression of hip osteoarthritis: predictive validity and responsiveness of a new computerized measure C.

Imaging biomarker with T1 and T2 mappings in osteoarthritis – In vivo human articular cartilage study C. Yan, C. Wong, T. Li, N. Gong, Q. Chan, K. Chiu

Nanoparticle targeting to cartilage: effects of surface charge on nanoparticle interactions with joint tissues S.B. Brown, B. Sharma Osteoarthritis.

Osteoarthritis year 2012 in review: biology

Osteoarthritis and Cartilage

Systematic review of the impact of osteoarthritis on health outcomes for comorbid disease in older people L. Parkinson, D.L. Waters, L. Franck Osteoarthritis.

Knee kinematic and kinetic modifications under body weight unloading during overground walking at a constant speed A.G. Fischer, E.M. Debbi, A. Wolf

Amyloid micronetworks for cartilage repair

Discovery of a small molecule inhibitor of the Wnt pathway (SM04690) as a potential disease modifying treatment for knee osteoarthritis J.D. Hood, V.

Quadriceps/Hamstrings co-activation during gait in individuals with anterior cruciate ligament reconstruction T. Blackburn, B. Pietrosimone, J. Goodwin,

Osteoarthritis year in review 2016: mechanics

Effects of propofol on the expression of matric metalloproteinases in rat cardiac fibroblasts after hypoxia and reoxygenation J.H. Jun, J.E. Cho, Y.H.

K. -C. Wang, E. Kwan, K. Aris, T. T. Egelhoff, A. I. Caplan, J. F

Concentrations of cytokines, matrix metalloproteinases, and tissue inhibitors of matrix metalloproteinases in autologous conditioned serum from horses.

General Information Osteoarthritis and Cartilage

Long-term effects of vitamin d supplementation and maintaining vitamin d sufficiency on knee osteoarthritis over 5 years B. Antony, S. Zheng, J. Burgess,

Presentation transcript:

Activation of Adenylyl Cyclase Reduces TGF-β Profibrotic Response in Osteoarthritic Fibroblast-Like Synoviocytes M. Qadri, R. Ostrom, K.A. Elsaid Osteoarthritis and Cartilage Volume 25, Pages S274-S275 (April 2017) DOI: 10.1016/j.joca.2017.02.465 Copyright © 2017 Terms and Conditions

Fig. 1. Impact of Forskolin (FsK) treatment (10μM) on transforming growth factor beta (TGF-β)-induced expression of collagen type I (COL1A1), collagen type III (COL3A1), α2 smooth muscle actin (ACTA2) and proteoglycan-4 (PRG4) in osteoarthritic fibroblast-like synoviocytes. SB431542 is a specific inhibitor of TGF-β signaling. *p<0.001; **p<0.01; ***p<0.05. FsK treatment reduced TGF-β induced COL1A1, COL3A1 and ACTA2 expression and increased TGF-β induced PRG4 expression. Osteoarthritis and Cartilage 2017 25, S274-S275DOI: (10.1016/j.joca.2017.02.465) Copyright © 2017 Terms and Conditions

Fig. 2. Impact of Forskolin (FsK) treatment (10μM) on transforming growth factor beta (TGF-β)-induced expression of matrix metalloproteinases 3, 9, and 13 (MMP3, 9 and 13), aggrecanase-1 (ADAMTS4) and tissue inhibitor of metalloproteinase-1 (TIMP1). *p<0.001; **p<0.01; ***p<0.05. FsK treatment reduced TGF-β induced MMP3, MMP9, MMP13, ADAMTS4 and TIMP1 expression. Osteoarthritis and Cartilage 2017 25, S274-S275DOI: (10.1016/j.joca.2017.02.465) Copyright © 2017 Terms and Conditions