A Dead End for MicroRNAs

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A Dead End for MicroRNAs René F. Ketting Cell Volume 131, Issue 7, Pages 1226-1227 (December 2007) DOI: 10.1016/j.cell.2007.12.004 Copyright © 2007 Elsevier Inc. Terms and Conditions

Figure 1 Dnd1 Promotes mRNA Stability (A) MicroRNAs (miRNAs) are part of a multisubunit complex, often referred to as miRISC. This complex can bind to mRNAs when a region in the mRNA (blue box) is homologous to the miRNA. MicroRNAs inhibit translation and decrease the stability of target mRNAs. (B) When the Dnd1 protein binds to a U-rich region in the mRNA (orange box), it can block recognition of the mRNA by miRISC, allowing translation of the mRNA. (C) Alternatively, Dnd1 may translocate the bound mRNA to structures that are inaccessible to miRISC, such as the germplasm of germ cells. Cell 2007 131, 1226-1227DOI: (10.1016/j.cell.2007.12.004) Copyright © 2007 Elsevier Inc. Terms and Conditions