Drug and Gene Delivery to the Brain

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Presentation transcript:

Drug and Gene Delivery to the Brain William M Pardridge Neuron Volume 36, Issue 4, Pages 555-558 (November 2002) DOI: 10.1016/S0896-6273(02)01054-1

Figure 1 Transvascular and Transcranial Drug Delivery to the Brain (A) India ink injection in adult rats shows the dense microvascular network within the brain (Bar, 1980). These brain capillaries form the BBB, and the delivery of drugs or genes across the BBB is the only pathway that enables widespread distribution of the drug to all cells within the brain. (B) Film autoradiogram of rat brain 48 hr after the intracerebral (IC) implantation of a biodegradable polymer containing [125I]-nerve growth factor (NGF) (Krewson et al., 1995). The distance bar is 2.5 mm, and the diameter of the polymer was 2 mm; therefore, there is minimal diffusion of the NGF into brain away from the IC implant. (C) Film autoradiogram of rat brain 24 hr after the ICV injection of [125I]-BDNF (Yan et al., 1994). The neurotrophin does not distribute into brain beyond the ipsilateral ependymal surface. Neuron 2002 36, 555-558DOI: (10.1016/S0896-6273(02)01054-1)