Volume 116, Issue 2, Pages 431-437 (February 1999) Effect of bacterial or porcine lipase with low- or high-fat diets on nutrient absorption in pancreatic-insufficient dogs  Ayako Suzuki, Akiyoshi Mizumoto, Rungsun Rerknimitr, Michael G. Sarr, Eugene P. DiMagno  Gastroenterology  Volume 116, Issue 2, Pages 431-437 (February 1999) DOI: 10.1016/S0016-5085(99)70141-1 Copyright © 1999 American Gastroenterological Association Terms and Conditions

Fig. 1 Dose response and correction of steatorrhea in 5 pancreatic-insufficient dogs fed a standard meal of 580 kcal (47% carbohydrate, 30% fat, and 23% protein) with 0–300,000 IU of pancreatin or 0–600,000 IU of BL. ▩, Normal dogs. Pancreatic-insufficient dogs: □, no treatment; ▨, BL; ■, PL. P < 0.05 among BL and PL (ANOVA); * P < 0.05 (paired t test); # P < 0.01 (paired t test). Gastroenterology 1999 116, 431-437DOI: (10.1016/S0016-5085(99)70141-1) Copyright © 1999 American Gastroenterological Association Terms and Conditions

Fig. 2 Effect of diets on correction of steatorrhea in 3 pancreatic-insufficient dogs fed a high C, low F & P meal and a low C, high F & P meal of 850 kcal with 135,000 IU and 300,000 IU of BL and 135,000 IU of PL. (A) □, High C, low F & P meal; ■, low C, high F & P meal. *P < 0.05 (paired t test). (B) Each symbol represents individual data in 3 dogs. ··♦··, 135,000 IU of BL; —◊—, 300,000 IU of BL; –*–, 135,000 IU of PL. Gastroenterology 1999 116, 431-437DOI: (10.1016/S0016-5085(99)70141-1) Copyright © 1999 American Gastroenterological Association Terms and Conditions

Fig. 3 Interaction among nutrient absorption, diets, and enzyme treatments in canine exocrine insufficiency. □, No enzyme; ▨, 135,000 IU of BL; ▩, 300,000 IU of BL; ■, 135,000 IU of PL. *P < 0.05 vs. all treatment; **P < 0.05 (paired t test); #P < 0.05 vs. high C, low F & P meal. Gastroenterology 1999 116, 431-437DOI: (10.1016/S0016-5085(99)70141-1) Copyright © 1999 American Gastroenterological Association Terms and Conditions

Fig. 4 Dose response and correction of steatorrhea in 2 pancreatic-insufficient dogs fed a standard meal or a low C, high F & P meal with 0–135,000 IU or 300,000 IU of pancreatin. Gastroenterology 1999 116, 431-437DOI: (10.1016/S0016-5085(99)70141-1) Copyright © 1999 American Gastroenterological Association Terms and Conditions