Re-cyclin’ Cell-Cycle Components to Make NETs

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Presentation transcript:

Re-cyclin’ Cell-Cycle Components to Make NETs Jean Albrengues, Robert W. Wysocki, Laura Maiorino, Mikala Egeblad Developmental Cell Volume 43, Issue 4, Pages 379-380 (November 2017) DOI: 10.1016/j.devcel.2017.11.002 Copyright © 2017 Elsevier Inc. Terms and Conditions

Figure 1 Similarities between Cell-Cycle Progression and NETosis Neutrophils are terminally differentiated cells, but they have hijacked features of cell-cycle progression to form neutrophil extracellular traps (NETs) through the suicide program termed NETosis. In this issue, Amulic et al. show that NETosis requires activation of cyclin-dependent kinases (CDKs) 4 and 6. In addition, NETosis is accompanied by other hallmarks of cell-cycle progression, including Ki-67 upregulation, phosphorylation of the retinoblastoma protein (pRb) and of nuclear lamins, breakdown of the nuclear envelope, and duplication of the centrosomes. However, NETosis does not result in DNA duplication, condensation of chromosomes, or cytokinesis. Instead, NETosis ends when NETs—chromatin with associated enzymes and toxins—are expelled from the neutrophil. Developmental Cell 2017 43, 379-380DOI: (10.1016/j.devcel.2017.11.002) Copyright © 2017 Elsevier Inc. Terms and Conditions