Epstein–Barr virus BZLF1 gene polymorphisms: malignancy related or geographically distributed variants? M.A. Lorenzetti, M. Gantuz, J. Altcheh, E. De.

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Epstein–Barr virus BZLF1 gene polymorphisms: malignancy related or geographically distributed variants? M.A. Lorenzetti, M. Gantuz, J. Altcheh, E. De Matteo, P.A. Chabay, M.V. Preciado Clinical Microbiology and Infection Volume 20, Issue 11, Pages O861-O869 (November 2014) DOI: 10.1111/1469-0691.12631 Copyright © 2014 European Society of Clinical Infectious Diseases Terms and Conditions

FIG. 1 Schematic figure showing the complete Zta protein sequence alignment obtained from clinical samples and variant reference sequences. IM indicates infectious mononucleosis samples and T indicates tumour samples. B95.8, Zta-A2, Zta-B2, Zta-B4 and Zta-C are the reference sequences. Black, grey and white boxes delimit Zta antigen domains and brackets delimit the three coding exons in BZLF1 gene. Ruler shows amino acid position. Only sequences with additional mutations to those described in the reference sequence are shown in the alignment. Clinical Microbiology and Infection 2014 20, O861-O869DOI: (10.1111/1469-0691.12631) Copyright © 2014 European Society of Clinical Infectious Diseases Terms and Conditions

FIG. 2 Phylogenetic reconstruction. Trees obtained from the alignment of the complete protein sequence of the BZLF1 gene from patients with infectious mononucleosis (IM) and Epstein–Barr virus (EBV) -associated lymphomas. Only oral secretions (OS) samples were included from IM patients because both compartments harboured the same variant. Prototype sequences for each BZLF1 variant (Zta-A1, A2, B1 to B5 and Zta-C) were characterized in ref. [8]. Bootstrap values obtained after 1000 resamplings are indicated. The scale bars represent a genetic distance calculated by the number of base substitutions per site of 0.05. (a) Sequences from all patients were included in the original alignment. Variants BZLF1-B4 and BZLF1-C appear as a single taxa in the tree because they only differ in the deletion of amino acid (aa) 127 and deleted positions are not compared by phylogenetic software. (b) Tree obtained from the alignment of those sequences which did not contain the deletion of aa 127. (c) Tree obtained from the alignment of those sequences which contained the deletion of aa 127. Clinical Microbiology and Infection 2014 20, O861-O869DOI: (10.1111/1469-0691.12631) Copyright © 2014 European Society of Clinical Infectious Diseases Terms and Conditions