Quantitative analysis of exhaled carbonyl compounds distinguishes benign from malignant pulmonary disease Michael Bousamra, MD, Erin Schumer, MS, MD,

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Presentation transcript:

Quantitative analysis of exhaled carbonyl compounds distinguishes benign from malignant pulmonary disease Michael Bousamra, MD, Erin Schumer, MS, MD, Mingxiao Li, PhD, Ralph J. Knipp, MS, Michael H. Nantz, PhD, Victor van Berkel, MD, PhD, Xiao-An Fu, PhD The Journal of Thoracic and Cardiovascular Surgery Volume 148, Issue 3, Pages 1074-1081 (September 2014) DOI: 10.1016/j.jtcvs.2014.06.006 Copyright © 2014 The American Association for Thoracic Surgery Terms and Conditions

Figure 1 The box plots of the 4 cancer markers for the healthy control, benign pulmonary disease patient and lung cancer patient groups. A, 2-Butanone; B, 3-hydroxy-2-butanone; C, 2-acetacetaldehyde; D, 4-hydroxyhexenal. P values apply to the benign versus lung cancer patient groups. The box plot presents the median, lower, and upper quartiles (25th to 75th percentiles). HC, Healthy control group; BN, benign pulmonary patient group; LC, lung cancer patient group; ESLC, early-stage lung cancer; 4-HHE, 4-hydroxyhexenal. The Journal of Thoracic and Cardiovascular Surgery 2014 148, 1074-1081DOI: (10.1016/j.jtcvs.2014.06.006) Copyright © 2014 The American Association for Thoracic Surgery Terms and Conditions

Figure 2 Elevated carbonyl markers (ECMs) and positron emission tomography (PET) results in early-stage lung cancer. False-negative PET scans (n = 6) are identified by red circles. All tumors >2.5 cm have ≥2 ECMs, 35 tumors are >2 cm and 19 are ≤2 cm. The Journal of Thoracic and Cardiovascular Surgery 2014 148, 1074-1081DOI: (10.1016/j.jtcvs.2014.06.006) Copyright © 2014 The American Association for Thoracic Surgery Terms and Conditions

Figure 3 Comparison of box plots of the 4 carbonyl markers before and after early-stage cancer resection. The box plot presents the median, lower, and upper quartiles (25th to 75th percentiles). A, 2-Butanone, P = .0001; B, 3-hydroxy-2-butanone, P = .164; C, 2-acetaldehyde, P = .0004; D, 4-hydroxyhexenal, P = .0005. 4-HHE, 4-hydroxyhexenal. The Journal of Thoracic and Cardiovascular Surgery 2014 148, 1074-1081DOI: (10.1016/j.jtcvs.2014.06.006) Copyright © 2014 The American Association for Thoracic Surgery Terms and Conditions