Volume 93, Issue 3, Pages (March 2018)

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Volume 93, Issue 3, Pages 530-531 (March 2018) Journal Club Kidney International Volume 93, Issue 3, Pages 530-531 (March 2018) DOI: 10.1016/j.kint.2018.01.003 Copyright © 2018 International Society of Nephrology Terms and Conditions

CD31 targeted nanoparticles (CD31-NP) show enhanced binding to human glomerular endothelial cells and interstitial microvessels compared with control nontargeted NP (control NP). Vascular endothelial stain (Ulex green); cell nuclei (4′,6-diamidino-2-phenylindole blue) nanoparticles (red). From Tietjen GT, Hosgood SA, DiRito J, et al. Nanoparticle targeting to the endothelium during normothermic machine perfusion of human kidneys. Sci Transl Med. 2017;9(418). pii: eaam6764. https://doi.org/10.1126/scitranslmed.aam6764. Reprinted with permission from the American Association for the Advancement of Science. Kidney International 2018 93, 530-531DOI: (10.1016/j.kint.2018.01.003) Copyright © 2018 International Society of Nephrology Terms and Conditions

Conserved steps in cell spreading and movement Conserved steps in cell spreading and movement. (i) Polymerization of actin filaments at the leading edge is translated into protrusive force. (ii) Membrane protrusion facilitates the binding of transmembrane cell surface receptors to the substratum components. New adhesions are rapidly linked to the network of actin filaments. (iii) The combined activity of retrograde actin movement and contractile forces produced by stress fibers generate tension to pull the cell body forward. (iv) The forces produced by the contractile network combined with actin filament and focal adhesion disassembly help to retract the trailing cell edge. (Note: the “space” between the cell and the substrate [shown as a gray bar] is exaggerated in this diagram.) Citation: MBInfo © 2017 National University of Singapore. Image provided courtesy of the Mechanobiology Institute, National University of Singapore. Kidney International 2018 93, 530-531DOI: (10.1016/j.kint.2018.01.003) Copyright © 2018 International Society of Nephrology Terms and Conditions