DKO CD8+ T cells demonstrate a strong effector response but altered memory differentiation and maintenance after LCMV infection. DKO CD8+ T cells demonstrate.

Slides:

Advertisements

Similar presentations

Fig. 1. Level of Mac-1 expression on naive and recently activated LCMV GP33–41-specific T cells from TCR 318 transgenic mice. (A and B) Splenocytes from.

Advertisements

Volume 45, Issue 2, Pages (August 2016)

Sustained Interactions between T Cell Receptors and Antigens Promote the Differentiation of CD4+ Memory T Cells Chulwoo Kim, Theodore Wilson, Kael F.

Initial T Cell Receptor Transgenic Cell Precursor Frequency Dictates Critical Aspects of the CD8+ T Cell Response to Infection Vladimir P. Badovinac,

Volume 36, Issue 6, Pages (June 2012)

Volume 8, Issue 2, Pages (February 1998)

Hans-Peter Raué, Carol Beadling, Jennifer Haun, Mark K. Slifka

Volume 25, Issue 11, Pages (November 2017)

MP cells, but not pathogen-elicited effector CD4+ T lymphocytes, rapidly produce IFN-γ during T. gondii infection independently of pathogen antigens. MP.

The role of CC chemokine receptor 5 in antiviral immunity

IL-2 consumption by highly activated CD8 T cells induces regulatory T-cell dysfunction in patients with hemophagocytic lymphohistiocytosis Stéphanie.

miR-150-Mediated Foxo1 Regulation Programs CD8+ T Cell Differentiation

Changes in splenic CD4+ and CD8+ T cell subsets during acute and chronic HIV infection in MISTRG mice. Changes in splenic CD4+ and CD8+ T cell subsets.

Loss of Runx2 in the T cell compartment leads to a defect in the number of CD8+ memory precursor T cells during LCMV–Armstrong infection. Loss of Runx2.

Volume 23, Issue 1, Pages (April 2018)

Volume 31, Issue 1, Pages (July 2009)

MP cells established in Rag γc KO mice are Toxoplasma antigen–unspecific T-bet+ population. MP cells established in Rag γc KO mice are Toxoplasma antigen–unspecific.

Prf1−/− mice exhibit increased immunopathology with prior CD8 T cell memory secondary to immunization. Prf1−/− mice exhibit increased immunopathology with.

Enhanced proliferation and cytokine production in DGKζ and Cbl-b deficient mice. Enhanced proliferation and cytokine production in DGKζ and Cbl-b deficient.

Loss of pathogen-specific T cell memory is due to the absence of Runx2 in CD8+ T cells. Loss of pathogen-specific T cell memory is due to the absence of.

Administration of pIL2 and pgDE7 induces higher activation of E7-specific Tem CD8+ T cells. Administration of pIL2 and pgDE7 induces higher activation.

Altered cytokine production by Klrk1−/− NOD CTL

Protective Capacity of Memory CD8+ T Cells Is Dictated by Antigen Exposure History and Nature of the Infection Jeffrey C. Nolz, John T. Harty Immunity

CD160−/− mice have impaired clearance of oral L

Regulatory CD4+ T cell–derived IL-10 is important for B cell differentiation and the GC response. Regulatory CD4+ T cell–derived IL-10 is important for.

Loss of DGKζ and Cbl-b results in a greater percentage of splenic CD8+ T cells with an activated phenotype. Loss of DGKζ and Cbl-b results in a greater.

Inflammatory APC show highest expression of TNF superfamily ligands in the lung after LCMV infection. Inflammatory APC show highest expression of TNF superfamily.

Volume 40, Issue 5, Pages (May 2014)

An Interleukin-21- Interleukin-10-STAT3 Pathway Is Critical for Functional Maturation of Memory CD8+ T Cells Weiguo Cui, Ying Liu, Jason S. Weinstein,

Adaptive immune responses and NK activity.

Volume 35, Issue 4, Pages (October 2011)

Volume 32, Issue 1, Pages (January 2010)

Human PBMC-derived MERS-CoV–specific T cells are multifunctional.

Eric A Butz, Michael J Bevan Immunity

Volume 39, Issue 1, Pages (July 2013)

Volume 13, Issue 6, Pages (November 2015)

Cell-Intrinsic IL-27 and gp130 Cytokine Receptor Signaling Regulates Virus-Specific CD4+ T Cell Responses and Viral Control during Chronic Infection

Matthew A. Williams, Eugene V. Ravkov, Michael J. Bevan Immunity

Volume 27, Issue 2, Pages (August 2007)

Blimp-1 expression is enhanced in both si-tolerant T cells and CD3/CD155-ligated T cells. Blimp-1 expression is enhanced in both si-tolerant T cells and.

Susan M. Kaech, Scott Hemby, Ellen Kersh, Rafi Ahmed Cell

Volume 16, Issue 12, Pages (September 2016)

High-dimensional analysis of effector CD4 T cell function following γHV68 infection in B6 and IL-10KO mice. High-dimensional analysis of effector CD4 T.

MP cells can mediate resistance in infectious models that induce TH1-type immunity. MP cells can mediate resistance in infectious models that induce TH1-type.

Ag 85A–specific immune responses.

Tfr cell–derived IL-10 is important for B cell differentiation and the GC response. Tfr cell–derived IL-10 is important for B cell differentiation and.

Volume 40, Issue 2, Pages (February 2014)

Volume 38, Issue 2, Pages (February 2013)

Volume 22, Issue 8, Pages (February 2018)

Attrition of T Cell Memory

TSG-6 suppressed APC activation in vitro and in vivo.

High numbers of non–islet-specific CTLs attenuate effector functions of islet-specific CTLs. High numbers of non–islet-specific CTLs attenuate effector.

MP cells, but not pathogen-elicited effector CD4+ T lymphocytes, rapidly produce IFN-γ during T. gondii infection independently of pathogen antigens. MP.

Volume 31, Issue 2, Pages (August 2009)

The number of islet antigen–specific T cells is reduced in CT-treated RIP-LCMV-GP mice. The number of islet antigen–specific T cells is reduced in CT-treated.

Members of IL-1 family of cytokines favor the generation of IL-3–secreting CD4+ T cells in vitro. Members of IL-1 family of cytokines favor the generation.

CD8 T cell memory alters the immune profile in enhanced HLH without altering viral load. CD8 T cell memory alters the immune profile in enhanced HLH without.

Spontaneous and strong Tfh cell but not Tfr cell development in IL-2 KO mice. Spontaneous and strong Tfh cell but not Tfr cell development in IL-2 KO mice.

CD25 surface expression and TCR signal strength predict T helper differentiation and memory potential of early effector T cells in vivo. CD25 surface expression.

Volume 38, Issue 4, Pages (April 2013)

DGKζ and Cbl-b deficient T Cells have enhanced ERK1/2 and IκBα phosphorylation. DGKζ and Cbl-b deficient T Cells have enhanced ERK1/2 and IκBα phosphorylation.

CD4+ memory T cells derived from either CD25hi or CD25lo effector cells respond robustly to secondary challenge. CD4+ memory T cells derived from either.

CD25 expression predicts effector and memory differentiation.

MDSC-derived IL-6 enhances tumor progression through the inhibition of tumor-specific TH1 development and of their helper activity for CD8+ T cells. MDSC-derived.

Mice with a B cell–specific deletion of Ets1 have increased memory phenotype B cells but no increase in switching to IgG1. Mice with a B cell–specific.

In vitro lymphokine responses of mesenteric LN cells from S

Supplementary Figure 1. The extrinsic acquisition of CD80 does not affect the cytotoxicity of Ag-specific memory CD8+ T cells. The LG and SP were obtained.

IL-9–expressing TH cells are highly enriched in CCR4+/CCR8+ effector memory TH cells. IL-9–expressing THcells are highly enriched in CCR4+/CCR8+effector.

Memory phenotypes PBMC-derived MERS-CoV-specific T cells from CWs

Volume 8, Issue 2, Pages (August 2010)

Presentation transcript:

DKO CD8+ T cells demonstrate a strong effector response but altered memory differentiation and maintenance after LCMV infection. DKO CD8+ T cells demonstrate a strong effector response but altered memory differentiation and maintenance after LCMV infection. WT and KO mice were infected with LCMV Armstrong. (A) Short-lived effector (KLRG1+CD127−) and memory precursor (KLRG1−CD127+) cells were examined from blood at 1, 2, 4, 6 wk postinfection. Six weeks postinfection, splenocytes were analyzed for gp33-LCMV–specific total CD8+ T cells (B) or short-lived effector cells and memory precursor effector cells (C). (D) Splenocytes were stimulated in vitro with GP33, NP369, and GP276 peptides. Graphs show the frequency of IFN-γ effector CD8+ T cells. Data from two pooled experiments. (n = 8–9 in each group). *p < 0.05, **p < 0.01, ***p < 0.001. ns, not significant. Erin M. Wesley et al. ImmunoHorizons 2018;2:107-118 Copyright © 2018 The Authors