Factors influencing the infant gut microbiome at age 3-6 months: Findings from the ethnically diverse Vitamin D Antenatal Asthma Reduction Trial (VDAART)

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Presentation transcript:

Factors influencing the infant gut microbiome at age 3-6 months: Findings from the ethnically diverse Vitamin D Antenatal Asthma Reduction Trial (VDAART) Joanne E. Sordillo, ScD, Yanjiao Zhou, MD, PhD, Michael J. McGeachie, PhD, John Ziniti, BA, Nancy Lange, MD, MPH, Nancy Laranjo, BA, Jessica R. Savage, MD, Vincent Carey, PhD, George O'Connor, MD, MS, Megan Sandel, MD, MPH, Robert Strunk, MD, PhD, Leonard Bacharier, MD, Robert Zeiger, MD, PhD, Scott T. Weiss, MD, MS, George Weinstock, PhD, Diane R. Gold, MD, MPH, Augusto A. Litonjua, MD, MPH Journal of Allergy and Clinical Immunology Volume 139, Issue 2, Pages 482-491.e14 (February 2017) DOI: 10.1016/j.jaci.2016.08.045 Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Race and the infant gut microbiome at age 3 to 6 months: composition of the top 20 most abundant taxa. A, African Americans. B, Caucasians. C, Hispanics. D, Other race. Journal of Allergy and Clinical Immunology 2017 139, 482-491.e14DOI: (10.1016/j.jaci.2016.08.045) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Mode of delivery and the infant gut microbiome at age 3 to 6 months: composition of the top 20 most abundant taxa. A, Vaginal delivery. B, C-section. Journal of Allergy and Clinical Immunology 2017 139, 482-491.e14DOI: (10.1016/j.jaci.2016.08.045) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 3 Breast-feeding and the infant gut microbiome at age 3 to 6 months: composition of the top 20 most abundant taxa. A, Breast fed ≥ 6 months. B, Breast fed < 6 months. Journal of Allergy and Clinical Immunology 2017 139, 482-491.e14DOI: (10.1016/j.jaci.2016.08.045) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E1 Central Human Microbiome Project Trees structure (family level) for C-section (A) and vaginal delivery (B); differences in hierarchical tree branches (above a confidence value of 10) with C-section are shown with blue arrows (P = .018 for comparison between 2 trees). Journal of Allergy and Clinical Immunology 2017 139, 482-491.e14DOI: (10.1016/j.jaci.2016.08.045) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E1 Central Human Microbiome Project Trees structure (family level) for C-section (A) and vaginal delivery (B); differences in hierarchical tree branches (above a confidence value of 10) with C-section are shown with blue arrows (P = .018 for comparison between 2 trees). Journal of Allergy and Clinical Immunology 2017 139, 482-491.e14DOI: (10.1016/j.jaci.2016.08.045) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E2 Central Human Microbiome Project Trees structure (family level) for infants breast-fed for 6 or more months (A) and breast-fed for less than 6 months or formula-fed (B); differences (above a confidence value of 10) in hierarchical tree with breast-feeding are shown with blue arrows. Journal of Allergy and Clinical Immunology 2017 139, 482-491.e14DOI: (10.1016/j.jaci.2016.08.045) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E2 Central Human Microbiome Project Trees structure (family level) for infants breast-fed for 6 or more months (A) and breast-fed for less than 6 months or formula-fed (B); differences (above a confidence value of 10) in hierarchical tree with breast-feeding are shown with blue arrows. Journal of Allergy and Clinical Immunology 2017 139, 482-491.e14DOI: (10.1016/j.jaci.2016.08.045) Copyright © 2016 American Academy of Allergy, Asthma & Immunology Terms and Conditions