Can U Turn ILC2s Up? Paul A. Muller, Daniel Mucida Cell

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Can U Turn ILC2s Up? Paul A. Muller, Daniel Mucida Cell Volume 171, Issue 4, Pages 742-744 (November 2017) DOI: 10.1016/j.cell.2017.10.013 Copyright © 2017 Terms and Conditions

Figure 1 Neuromedin U Amplification of ILC2 Responses (A) At steady state, neuromedin receptor 1 (NMUR1)-expressing ILC2s are abundant in the lungs and small intestine. Within both tissues, ILC2s are closely associated with neuromedin U (NMU)-positive neuronal cell bodies and fibers. (B) Upon exposure to type 2 immune inducing organisms such as house dust mites and N. brasiliensis, neurons in the lungs and intestine release NMU through unknown mechanisms. Activation of ILC2 NMUR1 by NMU leads to increased numbers of ILC2s and ILC2 cytokine production. Cell 2017 171, 742-744DOI: (10.1016/j.cell.2017.10.013) Copyright © 2017 Terms and Conditions