Prenatal phthalate exposure associates with low regulatory T-cell numbers and atopic dermatitis in early childhood: Results from the LINA mother-child.

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Prenatal phthalate exposure associates with low regulatory T-cell numbers and atopic dermatitis in early childhood: Results from the LINA mother-child study Gunda Herberth, PhD, Arkadiusz Pierzchalski, PhD, Ralph Feltens, PhD, Mario Bauer, PhD, Stefan Röder, PhD, Sven Olek, PhD, Denise Hinz, PhD, Michael Borte, PhD, Martin von Bergen, PhD, Irina Lehmann, PhD Journal of Allergy and Clinical Immunology Volume 139, Issue 4, Pages 1376-1379.e8 (April 2017) DOI: 10.1016/j.jaci.2016.09.034 Copyright © 2016 The Authors Terms and Conditions

Fig 1 Relationship between maternal urine phthalate metabolite concentrations and the number of Treg cells. Data represent samples with phthalate and Treg-cell measurements in pregnancy (n = 542) and with phthalate measurements in pregnancy and Treg cells in children in cord blood (n = 448) and at the age of 2 years (n = 331). Shown are the mean ratios with 95% CI. Mean ratios were adjusted for maternal atopic dermatitis, maternal smoking and/or ETS exposure at home during pregnancy, maternal education, cat ownership during pregnancy, and previous births. In addition, data from cord blood were adjusted for sex and those at the age of 2 years for sex and breast-feeding until 6 months. Journal of Allergy and Clinical Immunology 2017 139, 1376-1379.e8DOI: (10.1016/j.jaci.2016.09.034) Copyright © 2016 The Authors Terms and Conditions

Fig E1 Relationship between maternal urine phthalate metabolite concentrations and the number of Treg cells. Results based on the subgroup of children with available data for maternal urine phthalate concentrations in pregnancy as well as measurements of Treg cells in pregnancy, in children's cord blood, and at the age of 2 years (n = 208). Shown are the mean ratios with 95% CI. Mean ratios were adjusted for maternal atopic dermatitis, maternal smoking and/or ETS exposure at home during pregnancy, maternal education, cat ownership during pregnancy, and previous births. In addition, data from cord blood were adjusted for sex and those at the age of 2 years for sex and breast-feeding until 6 months. Journal of Allergy and Clinical Immunology 2017 139, 1376-1379.e8DOI: (10.1016/j.jaci.2016.09.034) Copyright © 2016 The Authors Terms and Conditions