John Blebea, MD, John C. Kerr, BA, Charles D. Franco, MD, Frank T

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Presentation transcript:

Technetium 99m pyrophosphate quantitation of skeletal muscle ischemia and reperfusion injury John Blebea, MD, John C. Kerr, BA, Charles D. Franco, MD, Frank T. Padberg, MD, Robert W. Hobson, MD Journal of Vascular Surgery Volume 8, Issue 2, Pages 117-124 (August 1988) DOI: 10.1016/0741-5214(88)90397-7 Copyright © 1988 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 1 Gracilis artery blood flow during reperfusion. Results reflect mean ± standard error of 10 muscles in each group. Journal of Vascular Surgery 1988 8, 117-124DOI: (10.1016/0741-5214(88)90397-7) Copyright © 1988 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 2 Segmental distribution of 99mTc-PYP along length of muscle after 6 hours of ischemia and 1 hour of reperfusion in five dogs. , Experimental animals; , control animals; *, p < 0.05; **, p < 0.01. Journal of Vascular Surgery 1988 8, 117-124DOI: (10.1016/0741-5214(88)90397-7) Copyright © 1988 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 3 Electron micrograph of normal control muscle. Glycogen granules (G) are present, myofibrils show normal structure and are in an orderly pattern, and the mitochondria (M) are normal in size and electron-dense with intact membranes (arrow). (Original magnification × 14,300.) Journal of Vascular Surgery 1988 8, 117-124DOI: (10.1016/0741-5214(88)90397-7) Copyright © 1988 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 4 Electron micrograph of gracilis muscle after 6 hours of ischemia and reperfusion. There is extensive intercellular edema (open squares) and myofibrillar disorganization and cytoplasm is depleted of glycogen. Mitochondria (M) are swollen with lysis of cristae (arrowhead) and the outer mitochondrial membrane has ruptured in some (arrow). (Original magnification × 14,300.) Journal of Vascular Surgery 1988 8, 117-124DOI: (10.1016/0741-5214(88)90397-7) Copyright © 1988 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions