Joint fluid antioxidants are decreased in osteoarthritic joints compared to joints with macroscopically intact cartilage and subacute injury E.A. Regan,

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Presentation transcript:

Joint fluid antioxidants are decreased in osteoarthritic joints compared to joints with macroscopically intact cartilage and subacute injury E.A. Regan, M.D., Ph.D., R.P. Bowler, M.D., Ph.D., J.D. Crapo, M.D. Osteoarthritis and Cartilage Volume 16, Issue 4, Pages 515-521 (April 2008) DOI: 10.1016/j.joca.2007.09.001 Copyright © 2007 Osteoarthritis Research Society International Terms and Conditions

Fig. 1 EC-SOD in human joint fluid. EC-SOD protein is very significantly decreased in joint fluid from osteoarthritic knee joints compared to subjects with mechanical symptoms or injury but with intact cartilage (controls=10.8±1.5pg EC-SOD per μg protein, OA fluid=5.6±0.9pg EC-SOD per μg protein, *F=15.8, P=0.004). EC-SOD as a catalytic scavenger has rate constant of 109 and is the most rapid and effective scavenger of superoxide in the extracellular spaces and fluids. This striking deficiency of antioxidant capacity could be a primary event due to failure of synthesis in either cartilage or synovium, or could be due to excessive degradation of the protein. If joints were stressed oxidatively by weight-bearing activity or by the unique degradative processes in OA, increased oxidant scavenging capacity would be an expected homeostatic response. The observed difference in joint fluid EC-SOD may aggravate the oxidative stress within the OA joint. Osteoarthritis and Cartilage 2008 16, 515-521DOI: (10.1016/j.joca.2007.09.001) Copyright © 2007 Osteoarthritis Research Society International Terms and Conditions

Fig. 2 Low molecular weight antioxidants in joint fluid. (A) Ascorbate showed greater than a 50% difference between the OA joint fluid compared to that from injured knees with macroscopically intact cartilage at arthroscopy (t=2.01, P=0.05). (B) Urate does not show a significant difference (t=−0.74, P=0.45) between groups. (C) Reduced GSH is significantly different between the two groups but linear regression modeling demonstrates only an age effect between the two groups with disease state and interactions eliminated from the model (F=9.4, P=0.004). (D) GSSG is also significantly different between the two groups but regression modeling (R2=0.498, F=4.25, P=0.002) demonstrates significant effects in the model from disease state, age, BMI and their interactions. Osteoarthritis and Cartilage 2008 16, 515-521DOI: (10.1016/j.joca.2007.09.001) Copyright © 2007 Osteoarthritis Research Society International Terms and Conditions

Fig. 3 IL-6 and TGF-beta in joint fluid. IL-6 and TGF-beta do not show a statistically significant difference between the comparison group and OA joint fluids. The mean values for injured samples compared to OA samples trend to increase in the arthritis patients as expected, but fail to reach significance. This may be due to the injured knees having altered cytokines and reflects the difficulties in defining control and disease groups well in arthritis studies due to the late onset of the disease and extensive range of possible etiologies in the final pathway of OA. Osteoarthritis and Cartilage 2008 16, 515-521DOI: (10.1016/j.joca.2007.09.001) Copyright © 2007 Osteoarthritis Research Society International Terms and Conditions