New insights into the physiologic basis for intermittent pneumatic limb compression as a therapeutic strategy for peripheral artery disease Ryan D. Sheldon,

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Presentation transcript:

New insights into the physiologic basis for intermittent pneumatic limb compression as a therapeutic strategy for peripheral artery disease Ryan D. Sheldon, MS, Bruno T. Roseguini, PhD, M. Harold Laughlin, PhD, Sean C. Newcomer, PhD Journal of Vascular Surgery Volume 58, Issue 6, Pages 1688-1696 (December 2013) DOI: 10.1016/j.jvs.2013.08.094 Copyright © 2013 Society for Vascular Surgery Terms and Conditions

Fig 1 Representative samples of (A and C) ultrasound/Doppler recordings and (B and D) corresponding digitalization (B and D) of limb hemodynamics during (A and B) high-frequency and (C and D) low-frequency intermittent pneumatic compression (IPC) treatment. The red lines indicate cuff inflation, and the green lines indicate cuff deflation. Note the oscillatory shear that occurs during cuff deflation during each respective treatment frequency. Importantly, high-frequency IPC doubles the proportion of each minute the limb is exposed to this state of oscillatory shear but has no acute detrimental effect on popliteal artery function. Figure adapted from Sheldon et al.5 Journal of Vascular Surgery 2013 58, 1688-1696DOI: (10.1016/j.jvs.2013.08.094) Copyright © 2013 Society for Vascular Surgery Terms and Conditions

Fig 2 Schematic representation of the proposed mechanisms that contribute to the clinical outcomes (ie, reduced resting and intermittent claudication, improved ankle-brachial index, improved limb salvage, and better quality of life) of intermittent pneumatic compression (IPC) therapy. The dashed-line box indicates that improved vascular function to IPC treatment is speculative because it has not been directly measured previously, as detailed in the text. A-V, Arterial-venous. Journal of Vascular Surgery 2013 58, 1688-1696DOI: (10.1016/j.jvs.2013.08.094) Copyright © 2013 Society for Vascular Surgery Terms and Conditions