Massive Recruitment of Type I Interferon Producing Plasmacytoid Dendritic Cells in Varicella Skin Lesions Gianni Gerlini, Giulia Mariotti, Beatrice Bianchi,

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Massive Recruitment of Type I Interferon Producing Plasmacytoid Dendritic Cells in Varicella Skin Lesions Gianni Gerlini, Giulia Mariotti, Beatrice Bianchi, Nicola Pimpinelli Journal of Investigative Dermatology Volume 126, Issue 2, Pages 507-509 (February 2006) DOI: 10.1038/sj.jid.5700052 Copyright © 2006 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 1 Plasmacytoid dendritic cells infiltrate varicella skin lesions and produce IFN-α/β. Representative cryostat serial sections of a varicella skin lesion were stained with anti-CD123, anti-BDCA2, anti-MxA, and anti-CXCR3 antibodies according to the alkaline phosphatase antialkaline phosphatase technique. The biopsy was performed at the edge of a recently developed vesicle. Samples of normal human skin from the cryomaterial archive of the Department of Dermatological Sciences of Florence were used as negative controls. Tonsils were used as positive control for BDCA2+ pDC. (a, d) Numerous cells, in the dermal infiltrate and within dilated vessels, are strongly stained by the monoclonal antibody against CD123, which also stains endothelial cells indicated by the arrows (a). At higher magnification, most of the CD123-positive cells exhibit a roundish shape (d). (b, e, g) A high number of cells stained positive for the BDCA2 molecule. BDCA2 expressing cells co-localize in the same areas of CD123-positive cells in the dermal infiltrate and within the vessels (b, e). BDCA2-expressing cells show a typical plasmacytoid morphology (e) and are found in large numbers within the vessels often adherent to the endothelial wall as indicated by the arrows (g). (c, f) Intense IFN-α/β activity is shown in varicella lesion by staining with an antibody against MxA. (h) Sections of tonsils were used as control for BDCA2. (i, j) Numerous CXCR3-expressing cells are shown in the dermal infiltrate often within the vessels. (k) Varicella section stained with an irrelevant anti-idiotype antibody for negative control. Bars=100μm (a, b, c, i, k), 30μm (d, e, f, g, h, j). Journal of Investigative Dermatology 2006 126, 507-509DOI: (10.1038/sj.jid.5700052) Copyright © 2006 The Society for Investigative Dermatology, Inc Terms and Conditions