Volume 26, Issue 3, Pages (March 2007)

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Presentation transcript:

Volume 26, Issue 3, Pages 278-279 (March 2007) Good for Goose, but Not for Gander: IL-2 Interferes with Th17 Differentiation Brigitta Stockinger Immunity Volume 26, Issue 3, Pages 278-279 (March 2007) DOI: 10.1016/j.immuni.2007.03.001 Copyright © 2007 Elsevier Inc. Terms and Conditions

Figure 1 The Differentiation of Effector CD4+ T Cells Is Shaped by Distinct Cytokines, STAT Proteins, and Transcription Factors Differentiation of Th17 cells is positively influenced by IL-6 and TGF-β, and STAT3 activation results in upregulation of the lineage-defining transcription factor RORγt. In contrast, the Th1 cell lineage is driven by IL-12-STAT4, IFN-γ-STAT1 pathways and the T-bet transcription factor. The Th2 lineage is dependent on IL-4, STAT6, and the GATA-3 transcription factor. IL-2 (exocrine or autocrine) positively regulates Th1 and Th2 cells but inhibits Th17 cell differentiation via activation of STAT5 and downregulation of RORγt. Immunity 2007 26, 278-279DOI: (10.1016/j.immuni.2007.03.001) Copyright © 2007 Elsevier Inc. Terms and Conditions