Assessment of the ITMIG Statement on the WHO Histological Classification and of the Eighth TNM Staging of Thymic Epithelial Tumors of a Series of 188.

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Presentation transcript:

Assessment of the ITMIG Statement on the WHO Histological Classification and of the Eighth TNM Staging of Thymic Epithelial Tumors of a Series of 188 Thymic Epithelial Tumors Alexandra Meurgey, MD, Nicolas Girard, MD, PhD, Claire Merveilleux du Vignaux, MSc, Jean-Michel Maury, MD, François Tronc, MD, Françoise Thivolet-Bejui, MD, Lara Chalabreysse, MD Journal of Thoracic Oncology Volume 12, Issue 10, Pages 1571-1581 (October 2017) DOI: 10.1016/j.jtho.2017.06.072 Copyright © 2017 International Association for the Study of Lung Cancer Terms and Conditions

Figure 1 Frequency of each International Thymic Malignancy Interest Group consensus major and minor morphological and immunohistochemical criteria among type A thymomas (n = 7) (A), type AB thymomas (n = 67) (B), type B1 thymomas (n = 17) (C), type B2 thymomas (n = 46) (D), type B3 thymomas (n = 25) (E), and thymic carcinomas (n = 15) (F). Journal of Thoracic Oncology 2017 12, 1571-1581DOI: (10.1016/j.jtho.2017.06.072) Copyright © 2017 International Association for the Study of Lung Cancer Terms and Conditions

Figure 2 Morphological and immunohistochemical criteria for diagnosis of thymic epithelial tumors: large lobular growth pattern in type AB thymoma (A), small lobular growth pattern in type B2 thymoma (B), metaplastic subtype in type AB thymoma (C), conventional subtype in type AB thymoma (D), diffuse expression of solute carrier family 2 member 1 in thymic carcinoma (E), zonal expression of solute carrier family 2 member 1 in type B3 thymoma (F), nuclear expression of p63 in type B1 thymoma (G), and nuclear expression of p63 in type B2 thymoma (H). A–D, hematoxylin-eosin-saffron; original magnification ×25; E–H, immunoperoxidase; original magnification, ×100). Journal of Thoracic Oncology 2017 12, 1571-1581DOI: (10.1016/j.jtho.2017.06.072) Copyright © 2017 International Association for the Study of Lung Cancer Terms and Conditions

Figure 3 Staging for 152 assessable thymic epithelial tumors of our cohort according to histological type. Switch from Masaoka-Koga stage to stage according to the eighth edition of the TNM staging classification (A), correlation between histological subtype and Masaoka-Koga stage (B), and correlation between histological subtype and stage according to the eighth edition of the TNM staging classification (C). Journal of Thoracic Oncology 2017 12, 1571-1581DOI: (10.1016/j.jtho.2017.06.072) Copyright © 2017 International Association for the Study of Lung Cancer Terms and Conditions

Figure 4 Time to recurrence according to completion of surgical resection (A), WHO histological type (C), Masaoka-Koga stage (E), and stage according to the eighth edition of the TNM staging classification (G). Overall survival according to completion of surgical resection (B), WHO histological type (D), Masaoka-Koga stage (F), and stage according to the eighth edition of the TNM staging classification (H). Journal of Thoracic Oncology 2017 12, 1571-1581DOI: (10.1016/j.jtho.2017.06.072) Copyright © 2017 International Association for the Study of Lung Cancer Terms and Conditions