Pregnancy-related complications and perinatal outcomes resulting from transfer of cryopreserved versus fresh embryos in vitro fertilization: a meta-analysis

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Presentation transcript:

Pregnancy-related complications and perinatal outcomes resulting from transfer of cryopreserved versus fresh embryos in vitro fertilization: a meta-analysis Tingting Sha, M.D., Xunqiang Yin, M.D., Wenwei Cheng, M.D., Isaac Yaw Massey, M.D. Fertility and Sterility Volume 109, Issue 2, Pages 330-342.e9 (February 2018) DOI: 10.1016/j.fertnstert.2017.10.019 Copyright © 2017 American Society for Reproductive Medicine Terms and Conditions

Figure 1 Flow diagram showing the detailed selection of studies included in the meta-analysis. Fertility and Sterility 2018 109, 330-342.e9DOI: (10.1016/j.fertnstert.2017.10.019) Copyright © 2017 American Society for Reproductive Medicine Terms and Conditions

Figure 2 Pregnancy-related complications in women after frozen-thawed embryo transfer (FET) versus fresh embryo transfer (ET). CI = confidence interval; RR = risk ratio. Fertility and Sterility 2018 109, 330-342.e9DOI: (10.1016/j.fertnstert.2017.10.019) Copyright © 2017 American Society for Reproductive Medicine Terms and Conditions

Supplemental Figure 1 Low birth weight in live births generated with the use of frozen-thawed versus fresh embryo transfer. Some of the studies provided both singleton (a) and twins (b) data. CI = confidence interval; RR = risk ratio. Fertility and Sterility 2018 109, 330-342.e9DOI: (10.1016/j.fertnstert.2017.10.019) Copyright © 2017 American Society for Reproductive Medicine Terms and Conditions

Supplemental Figure 2 Very low birth weight in live births generated with the use of frozen-thawed versus fresh embryo transfer. Some of the studies provided both singleton (a) and twins (b) data. CI = confidence interval; RR = risk ratio. Fertility and Sterility 2018 109, 330-342.e9DOI: (10.1016/j.fertnstert.2017.10.019) Copyright © 2017 American Society for Reproductive Medicine Terms and Conditions

Supplemental Figure 3 Premature birth in live births generated with the use of frozen-thawed versus fresh embryo transfer. Some of the studies provided both singleton (a) and twins (b) data. CI = confidence interval; RR = risk ratio. Fertility and Sterility 2018 109, 330-342.e9DOI: (10.1016/j.fertnstert.2017.10.019) Copyright © 2017 American Society for Reproductive Medicine Terms and Conditions

Supplemental Figure 4 Very preterm birth in live births generated with the use of frozen-thawed versus fresh embryo transfer. Some of the studies provided both singleton (a) and twins (b) data. CI = confidence interval; RR = risk ratio. Fertility and Sterility 2018 109, 330-342.e9DOI: (10.1016/j.fertnstert.2017.10.019) Copyright © 2017 American Society for Reproductive Medicine Terms and Conditions

Supplemental Figure 5 Small for gestational age in live births generated with the use of frozen-thawed versus fresh embryo transfer. Some of the studies provided both singleton (a) and twins (b) data. CI = confidence interval; RR = risk ratio. Fertility and Sterility 2018 109, 330-342.e9DOI: (10.1016/j.fertnstert.2017.10.019) Copyright © 2017 American Society for Reproductive Medicine Terms and Conditions

Supplemental Figure 6 Large for gestational age in live births generated with frozen-thawed embryo transfer versus fresh embryo transfer. Fertility and Sterility 2018 109, 330-342.e9DOI: (10.1016/j.fertnstert.2017.10.019) Copyright © 2017 American Society for Reproductive Medicine Terms and Conditions

Supplemental Figure 7 Perinatal mortality in pregnancies generated with the use of frozen-thawed versus fresh embryo transfer. Some of the studies provided both singleton (a) and twins (b) data. CI = confidence interval; RR = risk ratio. Fertility and Sterility 2018 109, 330-342.e9DOI: (10.1016/j.fertnstert.2017.10.019) Copyright © 2017 American Society for Reproductive Medicine Terms and Conditions

Supplemental Figure 8 Funnel plots of pregnancy-related complications. This figure tested the publication bias at three different statistics levels 90%, 95% and 99%: dark gray 0.1> P>.05, medium gray 0.05> P >.01, and light gray P< .01. GDM = gestational diabetes mellitus; PIH = pregnancy-induced hypertension. Fertility and Sterility 2018 109, 330-342.e9DOI: (10.1016/j.fertnstert.2017.10.019) Copyright © 2017 American Society for Reproductive Medicine Terms and Conditions

Supplemental Figure 9 Funnel plots of perinatal outcomes. This figure tested the the publication bias at three different statistics levels 90%, 95% and 99%: dark gray 0.1> P>.05, medium gray 0.05> P>.01, and light gray P<.01. LGA = large for gestational age; SGA = small for gestational age. Fertility and Sterility 2018 109, 330-342.e9DOI: (10.1016/j.fertnstert.2017.10.019) Copyright © 2017 American Society for Reproductive Medicine Terms and Conditions