Volume 62, Issue 3, Pages (March 2015)

Slides:



Advertisements
Similar presentations
EASL Clinical Practice Guidelines: Vascular diseases of the liver Journal of Hepatology Volume 64, Issue 1, Pages (January 2016) DOI: /j.jhep
Advertisements

Depression, anemia and health-related quality of life in chronic hepatitis C Amy A. Dan, Lisa M. Martin, Cathy Crone, Janus P. Ong, Denise W. Farmer, Thomas.
Omega 3 – Omega 6: What is right for the liver? Ashraf Mohammad El-Badry, Rolf Graf, Pierre-Alain Clavien Journal of Hepatology Volume 47, Issue 5, Pages.
Global gene repression in hepatocellular carcinoma and fetal liver, and suppression of dudulin-2 mRNA as a possible marker for the cirrhosis-to-tumor transition.
Volume 61, Issue 1, Pages (July 2014)
Volume 63, Issue 1, Pages (July 2015)
Volume 46, Issue 3, Pages (March 2007)
Inflammasomes in liver diseases
Volume 58, Issue 1, Pages (January 2013)
Lifestyle interventions for the treatment of non-alcoholic fatty liver disease in adults: A systematic review  Christian Thoma, Christopher P. Day, Michael.
MELD score is a better prognostic model than Child-Turcotte-Pugh score or Discriminant Function score in patients with alcoholic hepatitis  Wichit Srikureja,
The role of Epstein–Barr virus in acute and chronic hepatitis
The GAPs between hepatocellular carcinoma and RAS
Halis Simsek, Ali Shorbagi, Yasemin Balaban, Gonca Tatar 
Matthew T. Kitson, Stuart K. Roberts  Journal of Hepatology 
NS5A inhibitors in the treatment of hepatitis C
Volume 64, Issue 3, Pages (March 2016)
Immigration and viral hepatitis
Florie Borel, Pavlina Konstantinova, Peter L.M. Jansen 
Individualized prediction of hepatocellular carcinoma occurrence in a large cohort of patients with cirrhosis  Astrid Marot, Jean Henrion, Jean-François.
Living donor liver transplantation: is the hype over?
David G. Bowen, Christopher M. Walker  Journal of Hepatology 
The role of Epstein–Barr virus in acute and chronic hepatitis
Volume 69, Issue 2, Pages (August 2018)
Natural history and predictors of severity of chronic hepatitis C virus (HCV) and human immunodeficiency virus (HIV) co-infection  Anaïs Vallet-Pichard,
The place of downstaging for hepatocellular carcinoma
Volume 58, Issue 3, Pages (March 2013)
AST/platelet ratio index associates with progression to hepatic failure and correlates with histological fibrosis stage in Japanese patients with primary.
Telomeres and telomerase: new targets for the treatment of liver cirrhosis and hepatocellular carcinoma  André Lechel, Michael P. Manns, K.Lenhard Rudolph 
Cheng-Yuan Peng, Rong-Nan Chien, Yun-Fan Liaw  Journal of Hepatology 
Volume 68, Issue 1, Pages (January 2018)
Hepatitis C core protein – The “core” of immune deception?
Jean-Charles Nault, Peter R. Galle, Jens U. Marquardt 
Novel Mutations in the BHD Gene and Absence of Loss of Heterozygosity in Fibrofolliculomas of Birt-Hogg-Dubé Patients  Maurice A.M. van Steensel, Valerie.
Marc van der Valk, Hans L. Zaaijer, Arnon P. Kater, Janke Schinkel 
Riccardo Lencioni, Fabio Piscaglia, Luigi Bolondi 
Statin use and the risk of hepatocellular carcinoma in patients at high risk: A nationwide nested case-control study  Gyuri Kim, Suk-Yong Jang, Chung.
Volume 62, Issue 3, Pages (March 2015)
Volume 44, Issue 1, Pages (January 2006)
Volume 42, Issue 4, Pages (April 2005)
Genomic risk of hepatitis C-related hepatocellular carcinoma
Autophagy in the liver Journal of Hepatology
Volume 66, Issue 2, Pages (February 2017)
EASL Clinical Practice Guidelines: Wilson’s disease
Molecular prognostication of liver cancer: End of the beginning
Non-invasive diagnosis and biomarkers in alcohol-related liver disease
Volume 52, Issue 5, Pages (May 2010)
Paul C. Adams, James C. Barton  Journal of Hepatology 
Chetana Lim, Chady Salloum, Daniel Azoulay
Immigration and viral hepatitis
Evolution of liver transplantation for hepatocellular carcinoma
The potential of induced pluripotent stem cell derived hepatocytes
Kornelius Schulze, Jean-Charles Nault, Augusto Villanueva 
Clinical Practice Guidelines of the European Association for the study of the Liver – Advancing methodology but preserving practicability  Markus Cornberg,
HCV targeting of patients with cirrhosis
The impact of intestinal microflora on serum bilirubin levels
Volume 60, Issue 5, Pages (May 2014)
Role of desmoplasia in cholangiocarcinoma and hepatocellular carcinoma
Volume 63, Issue 1, Pages (July 2015)
Familial amyloidosis: Great progress for an orphan disease
Hepatitis C infection: A multi-faceted systemic disease with clinical, patient reported and economic consequences  Zobair M. Younossi, Aybike Birerdinc,
Volume 66, Issue 3, Pages (March 2017)
Volume 62, Issue 3, Pages (March 2015)
Integrating sorafenib into an algorithm for the management of post-transplant hepatocellular carcinoma recurrence  Christian Toso, Gilles Mentha, Pietro.
Pathogenesis of cholestatic hepatitis C
Genetic alterations in advanced HBV-related HCC with portal vein tumor thrombosis: Insights from next generation DNA sequencing  Roongruedee Chaiteerakij,
Chimeric mouse model of hepatitis B virus infection
Volume 50, Issue 1, Pages 4-6 (January 2009)
Genetics of hepatocellular carcinoma: The next generation
Reversion of disease manifestations after HCV eradication
Presentation transcript:

Volume 62, Issue 3, Pages 734-738 (March 2015) Biallelic inactivation of protoporphyrinogen oxidase and hydroxymethylbilane synthase is associated with liver cancer in acute porphyrias  Xiaoye Schneider-Yin, Anne-Moon van Tuyll van Serooskerken, Marko Siegesmund, Philip Went, Jasmin Barman-Aksözen, Reno S. Bladergroen, Paul Komminoth, Roy H.E. Cloots, Véronique J. Winnepenninckx, Axel zur Hausen, Markus Weber, Ann Driessen, Pamela Poblete-Gutiérrez, Peter Bauer, Christopher Schroeder, Michel van Geel, Elisabeth I. Minder, Jorge Frank  Journal of Hepatology  Volume 62, Issue 3, Pages 734-738 (March 2015) DOI: 10.1016/j.jhep.2014.11.029 Copyright © 2014 European Association for the Study of the Liver Terms and Conditions

Fig. 1 Sequence analyses of the PPOX and HMBS genes in patients with acute porphyria and hepatocellular carcinoma. Partial sequences of the PPOX gene, obtained by analyzing the liver cancer tissue from a VP patient, show (A) an insertion of nucleotide C at position 1080 (c.1082dupC) in exon 10 and (B) a nonsense mutation p.Lys416stop (AAG→TAG) in exon 11. Partial sequence of the HMBS gene, obtained by analyzing the liver cancer tissue from an AIP patient, show (C) a missense mutation p.Gly111Arg (GGA→AGA) in exon 7 and (D) a nonsense mutation p.Leu220stop (TTG→TAG) in exon 12. (This figure appears in color on the web.) Journal of Hepatology 2015 62, 734-738DOI: (10.1016/j.jhep.2014.11.029) Copyright © 2014 European Association for the Study of the Liver Terms and Conditions

Fig. 2 Microscopic examination of hepatic tumor tissues. (A) HePar-1 and (B) glypican-3 immunostaining of the hepatic tumor tissue from a VP patient (20×). (C) Immunohistochemical assessment of PPOX in the VP patient. Note the almost complete absence of PPOX expression in the cancerous liver tissue as compared to the non-cancerous liver section. (D) Immunohistochemical assessment of PPOX in a non-porphyric control individual with HCC. No differences in PPOX expression are detectable comparing the cancerous and non-cancerous liver sections. (C and D: 10×). (This figure appears in color on the web.) Journal of Hepatology 2015 62, 734-738DOI: (10.1016/j.jhep.2014.11.029) Copyright © 2014 European Association for the Study of the Liver Terms and Conditions