Making Biological Sense of GWAS Data: Lessons from the FTO Locus

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Making Biological Sense of GWAS Data: Lessons from the FTO Locus Mark A. Herman, Evan D. Rosen Cell Metabolism Volume 22, Issue 4, Pages 538-539 (October 2015) DOI: 10.1016/j.cmet.2015.09.018 Copyright © 2015 Elsevier Inc. Terms and Conditions

Figure 1 Variants in the FTO Locus Regulate IRX3/5 Expression to Exert Effects on Body Weight Top: Variants in the FTO locus regulate the expression of IRX3 and IRX5 via binding the transcription factor ARID5B. Bottom: The consequences of altered IRX3/5 expression may be manifested in the adipose lineage, with altered beige fat development, and/or in the hypothalamus, via changes in food intake and energy expenditure. See text for details. Cell Metabolism 2015 22, 538-539DOI: (10.1016/j.cmet.2015.09.018) Copyright © 2015 Elsevier Inc. Terms and Conditions