Circulating CD14+CD204+ Cells Predict Postoperative Recurrence in Non–Small-Cell Lung Cancer Patients Ryo Maeda, MD, Genichiro Ishii, MD, PhD, Shinya.

Slides:

Advertisements

Similar presentations

Lung Adenocarcinoma with Ipsilateral Breast Metastasis: A Simple Coincidence? Hsu-Ching Huang, MD, Jen-Fan Hang, MD, Mei-Han Wu, MD, Teh-Ying Chou, MD,

Advertisements

Clinical and the Prognostic Characteristics of Lung Adenocarcinoma Patients with ROS1 Fusion in Comparison with Other Driver Mutations in East Asian Populations

Foxp3+ Regulatory T Cells and Natural Killer Cells Distinctly Infiltrate Primary Tumors and Draining Lymph Nodes in Pulmonary Adenocarcinoma Thomas Schneider,

Comprehensive Pathological Analyses in Lung Squamous Cell Carcinoma: Single Cell Invasion, Nuclear Diameter, and Tumor Budding Are Independent Prognostic.

Next Generation Sequencing Uncovers Potential Genetic Driver Mutations of Malignant Pulmonary Granular Cell Tumor Song Xu, Qingchun Zhao, Sen Wei, Yi.

Disparities in Treatment of Patients with Inoperable Stage I Non–Small Cell Lung Cancer: A Population-Based Analysis Matthew Koshy, MD, Renuka Malik,

A Novel Classification of MUC1 Expression Is Correlated with Tumor Differentiation and Postoperative Prognosis in Non–Small Cell Lung Cancer Shinjiro.

Heterogeneity of Anaplastic Lymphoma Kinase Gene Rearrangement in Non–Small-Cell Lung Carcinomas: A Comparative Study Between Small Biopsy and Excision.

Long-Term Survival in Two Cases of Resected Gastric Metastasis of Pulmonary Pleomorphic Carcinoma Keiju Aokage, MD, Junji Yoshida, MD, Genichiro Ishii,

Sunny Guin, PhD, Yuanbin Ru, PhD, Murry W

Intraoperative detection of lymph node micrometastasis with flow cytometry in non– small cell lung cancer Manabu Ito, MD, Yoshihiro Minamiya, MD, PhD,

Significance of P53 and Rb protein expression in surgically treated non-small cell lung cancers Yung-Chie Lee, MD, PhD, Yih-Leong Chang, MD, Shi-Ping.

Impact of tumor size on outcomes after anatomic lung resection for stage 1A non–small cell lung cancer based on the current staging system Shamus R.

Significance of Programmed Cell Death-Ligand 1 Expression and its Association with Survival in Patients with Small Cell Lung Cancer Hidenobu Ishii, MD,

Prognostic Impact of CD204-Positive Macrophages in Lung Squamous Cell Carcinoma: Possible Contribution of Cd204-Positive Macrophages to the Tumor-Promoting.

Joachim Pfannschmidt, MD, Hans Hoffmann, MD, Hendrick Dienemann, MD

KRAS Mutation Analysis Helps to Differentiate Between Pulmonary Metastasis from Colon Adenocarcinoma In Situ and Primary Lung Adenocarcinoma Taylor M.

Tetsuya Mitsudomi, MD, Hirohito Tada, MD Journal of Thoracic Oncology

Electronic Updates for JTO Readers

Foxp3+ Regulatory T Cells and Natural Killer Cells Distinctly Infiltrate Primary Tumors and Draining Lymph Nodes in Pulmonary Adenocarcinoma Thomas Schneider,

Muhammad Umair Khawar, MD, Bhaskar Bhardwaj, MD, Himanshu Bhardwaj, MD

Mediastinal Nodal Involvement in Patients with Clinical Stage I Non–Small-Cell Lung Cancer: Possibility of Rational Lymph Node Dissection Tomohiro Haruki,

Central versus Peripheral Tumor Location: Influence on Survival, Local Control, and Toxicity Following Stereotactic Body Radiotherapy for Primary Non–Small-Cell.

Iwao Takanami, MD, Ken Takeuchi, MD, Masatoshi Giga, MD

Pneumonectomy-Sparing NSAID Therapy for Pulmonary Inflammatory Myofibroblastic Tumor Sofia Ghani, MD, Arpita Desai, MD, Saraswati Pokharel, MD, Todd.

Telomere Length and Recurrence Risk after Curative Resection in Patients with Early- Stage Non–Small-Cell Lung Cancer: A Prospective Cohort Study Eric.

PD-L1 Is Upregulated by Simultaneous Amplification of the PD-L1 and JAK2 Genes in Non–Small Cell Lung Cancer Seiichi Ikeda, MSc, Tatsuro Okamoto, MD,

Predictors of Death, Local Recurrence, and Distant Metastasis in Completely Resected Pathological Stage-I Non–Small-Cell Lung Cancer Jung-Jyh Hung, MD,

Multiple Pulmonary Chondroid Hamartoma

Mediastinal Lymph Node Examination and Survival in Resected Early-Stage Non– Small-Cell Lung Cancer in the Surveillance, Epidemiology, and End Results.

Prognostic Factors Based on Clinicopathological Data Among the Patients with Resected Peripheral Squamous Cell Carcinomas of the Lung Tomonari Kinoshita,

Expression of PD-1 and Its Ligands, PD-L1 and PD-L2, in Smokers and Never Smokers with KRAS-Mutant Lung Cancer Antonio Calles, MD, Xiaoyun Liao, MD,

Intratumoral Lymphatic Vessel Involvement is an Invasive Indicator of Completely Resected Pathologic Stage I Non-small Cell Lung Cancer Masahiko Harada,

Influence of Cigarette Smoking on Survival and Tumor Invasiveness in Clinical Stage IA Lung Adenocarcinoma Ryo Maeda, MD, Junji Yoshida, MD, Genichiro.

Perioperative cyclooxygenase 2 inhibition to reduce tumor cell adhesion and metastatic potential of circulating tumor cells in non–small cell lung cancer

Volume 67, Issue 4, Pages (April 2005)

Socioeconomic Status Is Associated with Depressive Severity Among Patients with Advanced Non–Small-Cell Lung Cancer: Treatment Setting and Minority Status.

Elizabeth B. Gottlin, PhD, Rex C. Bentley, MD, Michael J

New IASLC/ATS/ERS Classification and Invasive Tumor Size are Predictive of Disease Recurrence in Stage I Lung Adenocarcinoma Naoki Yanagawa, MD, PhD,

The correlation between tumor size and lymphatic vessel invasion in resected peripheral stage I non-small-cell lung cancer Yukito Ichinose, MDa, Tokujiro.

Tumor-Infiltrating Foxp3+ Regulatory T Cells are Correlated with Cyclooxygenase-2 Expression and are Associated with Recurrence in Resected Non-small.

Primary Malignant Pericardial Mesothelioma Mimicking Pericardial Metastasis from Adenocarcinoma Masafumi Horie, MD, Satoshi Noguchi, MD, Wakae Tanaka,

Extratumoral Vascular Invasion Is a Significant Prognostic Indicator and a Predicting Factor of Distant Metastasis in Non-small Cell Lung Cancer Yoshihisa.

Patterns of Disease Recurrence after SABR for Early Stage Non–Small-Cell Lung Cancer: Optimizing Follow-Up Schedules for Salvage Therapy Naomi E. Verstegen,

Histopathologic Features of the Tumor Budding in Adenocarcinoma of the Lung: Tumor Budding As an Index to Predict the Potential Aggressiveness Yoko Yamaguchi,

Results of surgical intervention for p-stage IIIA (N2) non–small cell lung cancer: Acceptable prognosis predicted by complete resection in patients with.

Neutrophil–Lymphocyte and Platelet–Lymphocyte Ratios as Prognostic Factors after Stereotactic Radiation Therapy for Early-Stage Non–Small-Cell Lung Cancer

Prognostic Impact of Node Involvement Pattern in Pulmonary pN1 Squamous Cell Carcinoma Patients Masayuki Nakao, MD, Junji Yoshida, MD, PhD, Genichiro.

Fibrous Stroma Is Associated with Poorer Prognosis in Lung Squamous Cell Carcinoma Patients Yusuke Takahashi, MD, Genichiro Ishii, MD, Tetsuhiko Taira,

Iris Metastasis in Small-Cell Lung Carcinoma

ALK Translocation in Non-small Cell Lung Cancer with Adenocarcinoma and Squamous Cell Carcinoma Markers Samuel J. Klempner, MD, David W. Cohen, MD, Daniel.

Mitotic Inhibitors Journal of Thoracic Oncology

Osimertinib for Epidermal Growth Factor Receptor Mutation–Positive Lung Adenocarcinoma That Transformed to T790M-Positive Squamous Cell Carcinoma Naoyuki.

Predictive Value of Intratumoral Microvascular Density in Patients with Advanced Non- small Cell Lung Cancer Receiving Chemotherapy Plus Bevacizumab Yuan-Yuan.

Stromal Macrophage Expressing CD204 is Associated with Tumor Aggressiveness in Lung Adenocarcinoma Yoichi Ohtaki, MD, Genichiro Ishii, MD, PhD, Kanji.

Clinical and the Prognostic Characteristics of Lung Adenocarcinoma Patients with ROS1 Fusion in Comparison with Other Driver Mutations in East Asian Populations

Visceral Pleural Invasion Classification in Non-small Cell Lung Cancer

EGFR Mutation and Brain Metastasis in Pulmonary Adenocarcinomas

CD4+ T lymphocytes mediate acute pulmonary ischemia–reperfusion injury

The Prognostic Impact of Cigarette Smoking on Patients with Non-small Cell Lung Cancer Ryo Maeda, MD, Junji Yoshida, MD, PhD, Genichiro Ishii, MD, PhD,

Comprehensive Pathological Analyses in Lung Squamous Cell Carcinoma: Single Cell Invasion, Nuclear Diameter, and Tumor Budding Are Independent Prognostic.

Adjuvant Surgery after Carboplatin and VP16 in Resectable Small Cell Lung Cancer Giulia Veronesi, MD, Paolo Scanagatta, MD, Francesco Leo, MD, Tommaso.

Jie Huang, Juan Peng, Linlang Guo, MD, PhD

Long-Term Outcomes of 50 Cases of Limited-Resection Trial for Pulmonary Ground- Glass Opacity Nodules Masayuki Nakao, MD, Junji Yoshida, MD, PhD, Koichi.

Wedge Resection for Non-small Cell Lung Cancer in Patients with Pulmonary Insufficiency: Prospective Ten-Year Survival John P. Griffin, MD, Charles E.

Who should decide margin length in pulmonary excision of lung cancer?

A B3 Type-Thymoma in a 7-Year-Old Child with Myasthenia Gravis

Effect of Tumor Size on Prognosis in Patients Treated with Radical Radiotherapy or Chemoradiotherapy for Non–Small Cell Lung Cancer: An Analysis of the.

Elevated Preoperative C-reactive Protein Predicts Poor Cancer Specific Survival in Patients Undergoing Resection for Non-small Cell Lung Cancer Caroline.

Biomarkers in Early-Stage Non–Small-Cell Lung Cancer: Current Concepts and Future Directions Mauricio Burotto, MD, Anish Thomas, MD, Deepa Subramaniam,

Presentation transcript:

Circulating CD14+CD204+ Cells Predict Postoperative Recurrence in Non–Small-Cell Lung Cancer Patients Ryo Maeda, MD, Genichiro Ishii, MD, PhD, Shinya Neri, MD, Kazuhiko Aoyagi, PhD, Hironori Haga, MD, PhD, Hiroki Sasaki, MD, PhD, Kanji Nagai, MD, PhD, Atsushi Ochiai, MD, PhD Journal of Thoracic Oncology Volume 9, Issue 2, Pages 179-188 (February 2014) DOI: 10.1097/JTO.0000000000000044 Copyright © 2014 International Association for the Study of Lung Cancer Terms and Conditions

FIGURE 1 Cell surface protein expression of CD204 on CD14+ cells from PA cultured in lung cancer cell line–conditioned medium. A, Blood samples from ligated PA of surgically resected lungs. Change in cell surface protein expressions of CD204 on CD14+ cells as determined using flow cytometry. B, Blood samples from ligated PA of surgically resected lungs. Change in cell surface protein expressions of CD204 on CD14+ cells as determined using flow cytometry. B, Change in CD204 cells per CD14 cell ratio (n = 4 for each group). *Compared with cases cultured in fibroblast-conditioned medium (all, p < 0.05). PA, pulmonary artery; FITC, fluorescein isothiocyanate. Journal of Thoracic Oncology 2014 9, 179-188DOI: (10.1097/JTO.0000000000000044) Copyright © 2014 International Association for the Study of Lung Cancer Terms and Conditions

FIGURE 2 Correlation among the number of CD204+ macrophages infiltrating the stroma of the primary tumor and the recurrence-free probability in stage I adenocarcinoma patients. A, Immunohistochemical staining for CD204 in lung cancer specimens. The sections were obtained from tumor specimens with low or high levels of CD204+ cells. B, Significantly more cases with a high number of CD204+ macrophages develop early recurrence within 3 years after resection (p < 0.01).C, CD204+ macrophages are found not only in the stroma of the tumor but also in intratumoral blood vessels. H.E., hematoxylin and eosin staining (×200); VVG, Victoria blue van Gieson staining (×200); CD204, CD204 staining (×200). Journal of Thoracic Oncology 2014 9, 179-188DOI: (10.1097/JTO.0000000000000044) Copyright © 2014 International Association for the Study of Lung Cancer Terms and Conditions

FIGURE 3 Correlation among the number of CD204+ macrophages infiltrating the stroma of the primary tumor, the number of CD14+CD204+ cells from the PV, and the probability of postoperative recurrence in lung cancer patients. A, Quantification of CD14+CD204+ cells among blood mononuclear cells from the PV. Representative data for two flow cytometry analyses. B, The number of CD14+CD204+ cells from the PV is correlated with the number of CD204+ macrophages in the stroma of the primary tumor. R = 0.658. *p < 0.05. C, A significantly greater number of CD204+ macrophages in the stroma are observed among the patients with high levels of CD14+CD204+ cells from the PV. D, Significantly more cases with a high number of CD14+CD204+ cells from the PV develop early recurrence within 2 years after resection (p < 0.01). PV, pulmonary vein. Journal of Thoracic Oncology 2014 9, 179-188DOI: (10.1097/JTO.0000000000000044) Copyright © 2014 International Association for the Study of Lung Cancer Terms and Conditions

FIGURE 4 CD14+CD204+ cells facilitated the lung metastasis of cancer cells more effectively than CD14+CD204− cells. A, Matrigel invasion assay. A significantly increased number of invading A549 cells on the lower surface of the filters is identified when CD14+CD204+ cells are added. *p < 0.05. B, CD14+CD204+ cells promote the metastasis of A549 cancer cells. *p < 0.05. C, Our concept that CD204+ tumor–associated macrophages remote from the primary tumor directly contribute to the metastasis of cancer cells at distant sites. Journal of Thoracic Oncology 2014 9, 179-188DOI: (10.1097/JTO.0000000000000044) Copyright © 2014 International Association for the Study of Lung Cancer Terms and Conditions