Vikas Chander, PhD, Kanwaljit Chopra, PhD Journal of Vascular Surgery

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Role of nitric oxide in resveratrol-induced renal protective effects of ischemic preconditioning Vikas Chander, PhD, Kanwaljit Chopra, PhD Journal of Vascular Surgery Volume 42, Issue 6, Pages 1198-1205 (December 2005) DOI: 10.1016/j.jvs.2005.08.032 Copyright © 2005 The Society for Vascular Surgery Terms and Conditions

Fig 1 Effect of ischemic preconditioning on serum creatinine (A), blood urea nitrogen (BUN) (B), and creatinine clearance (C) in ischemic reperfused rats. Values are expressed as mean ± SEM. *P < .05 compared with the sham group; **P < .05 compared with the ISC group (one-way analysis of variance followed by the Dunnett test). Prec 2/5, Three cycles of 2 minutes of ischemia and 5 minutes of reperfusion and 45 minutes of prolonged ischemia followed by 24 hours of reperfusion; Prec 3/5, three cycles of 3 minutes of ischemia and 5 minutes of reperfusion and 45 minutes of prolonged ischemia followed by 24 hours of reperfusion; Prec 4/5, three cycles of 4 minutes of ischemia and 5 minutes of reperfusion and 45 minutes of prolonged ischemia followed by 24 hours of reperfusion; Prec 5/5, three cycles of 5 minutes of ischemia and 5 minutes of reperfusion and 45 minutes of prolonged ischemia followed by 24 hours of reperfusion. Journal of Vascular Surgery 2005 42, 1198-1205DOI: (10.1016/j.jvs.2005.08.032) Copyright © 2005 The Society for Vascular Surgery Terms and Conditions

Fig 2 Hematoxylin and eosin–stained sections of rat kidneys. A, Renal cortex of rats from the sham group showing normal glomeruli and normal tubules. B, Renal cortex of ISC rats showing severe tubulointerstitial damage, hyaline casts, and medullary congestion. C, Kidney section of a rat treated with the Prec 2/5 protocol (three cycles of 2 minutes of ischemia and 5 minutes of reperfusion and 45 minutes of prolonged ischemia followed by 24 hours of reperfusion) showing only mild medullary congestion. D, Kidney section of a rat treated with resveratrol and ISC showing only mild tubular damage. E, Kidney section of rats treated with resveratrol in the ischemic preconditioning (IP) group showing almost normal morphology. F, Kidney section of rats treated with NG-nitro-l-arginine methyl ester (l-NAME) in the IP group showing severe tubular damage, cast formation, and medullary congestion. G, Kidney section of rats treated with resveratrol and l-NAME in the IP group showing moderate tubular damage, severe medullary congestion, and cast formation. H, Kidney section of rats treated with l-NAME in the ISC group showing severe tubular damage, cast formation, and medullary congestion. Journal of Vascular Surgery 2005 42, 1198-1205DOI: (10.1016/j.jvs.2005.08.032) Copyright © 2005 The Society for Vascular Surgery Terms and Conditions

Fig 3 Effect of ischemic preconditioning (IP) on tissue (A) and urine (B) total nitric oxide (NO) levels. Values are expressed as mean ± SEM. *P < .05 compared with the sham group; **P < .05 compared with the ISC group (one-way analysis of variance followed by the Dunnett test). ISC, Ischemic group; IP+ISC, preconditioned group; NO-ISC, resveratrol + ischemic group; NO-IP, resveratrol + preconditioned group; NA-IP, l-NAME + preconditioned group; NO-NA-IP, resveratrol + l-NAME + preconditioned group; NA-ISC, l-NAME + ischemic group. Journal of Vascular Surgery 2005 42, 1198-1205DOI: (10.1016/j.jvs.2005.08.032) Copyright © 2005 The Society for Vascular Surgery Terms and Conditions