Nitrofurantoin's efficacy and safety as prophylaxis for urinary tract infections: a systematic review of the literature and meta-analysis of controlled.

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Presentation transcript:

Nitrofurantoin's efficacy and safety as prophylaxis for urinary tract infections: a systematic review of the literature and meta-analysis of controlled trials A.E. Muller, E.M. Verhaegh, S. Harbarth, J.W. Mouton, A. Huttner Clinical Microbiology and Infection Volume 23, Issue 6, Pages 355-362 (June 2017) DOI: 10.1016/j.cmi.2016.08.003 Copyright © 2016 European Society of Clinical Microbiology and Infectious Diseases Terms and Conditions

Fig. 1 Flow chart of the retrieval of studies evaluated in the meta-analysis of the efficacy of nitrofurantoin prophylaxis. Clinical Microbiology and Infection 2017 23, 355-362DOI: (10.1016/j.cmi.2016.08.003) Copyright © 2016 European Society of Clinical Microbiology and Infectious Diseases Terms and Conditions

Fig. 2 Results of the meta-analysis for the prevention of urinary tract infection (UTI) when nitrofurantoin is compared with placebo/nothing. R, duration of prophylaxis; d, days; w, weeks; m, months; C-, comparator; F, female; M, male; O, duration of observation; A, adult; C, child. Clinical Microbiology and Infection 2017 23, 355-362DOI: (10.1016/j.cmi.2016.08.003) Copyright © 2016 European Society of Clinical Microbiology and Infectious Diseases Terms and Conditions

Fig. 3 Results of the meta-analysis for the prevention of urinary tract infection (UTI) when nitrofurantoin is compared with other antibiotics for short-term prophylaxis. R, duration of prophylaxis; d, days; C-, comparator; F, female; M, male; O, duration of observation; TMP/SXT, trimethoprim/sulfamethoxazole; CFR, cefadroxil; CIP, ciprofloxacin. Clinical Microbiology and Infection 2017 23, 355-362DOI: (10.1016/j.cmi.2016.08.003) Copyright © 2016 European Society of Clinical Microbiology and Infectious Diseases Terms and Conditions

Fig. 4 Results of the meta-analysis for the prevention of urinary tract infection (UTI) when nitrofurantoin is compared with other antibiotics used for long-term prophylaxis. R, duration of prophylaxis; d, days; C-, comparator; F, female; M, male; A, adult; C, child; PEN, penicillin; AMX, amoxicillin; PMC, pivmecillinam; CEC, cefaclor; CFX, cefixime; CIN, cinoxacin; NOR, norfloxacin; TMP/SXT, trimethoprim/sulfamethoxazole; TRM, trimethoprim; MH, methenamine hippurate; MM, methenamine mandelate; SMT, sulfamethizole; MAN, d-mannose. Clinical Microbiology and Infection 2017 23, 355-362DOI: (10.1016/j.cmi.2016.08.003) Copyright © 2016 European Society of Clinical Microbiology and Infectious Diseases Terms and Conditions

Fig. 5 Results of the meta-analysis for (mild) adverse effects for long-term use of nitrofurantoin compared with other antibiotics. R, duration of prophylaxis; d, days; C-, comparator; F, female; M, male; A, adult; C, child; PEN, penicillin; AMX, amoxicillin; PMC, pivmecillinam; CEC, cefaclor; CFX, cefixime; CIN, cinoxacin; NOR, norfloxacin; TMP/SXT, trimethoprim/sulfamethoxazole; TRM, trimethoprim; MH, methenamine hippurate; MM, methenamine mandelate; SMT, sulfamethizole; MAN, d-mannose. Clinical Microbiology and Infection 2017 23, 355-362DOI: (10.1016/j.cmi.2016.08.003) Copyright © 2016 European Society of Clinical Microbiology and Infectious Diseases Terms and Conditions