Follicle-stimulating hormone receptor polymorphism (Thr307Ala) is associated with variable ovarian response and ovarian hyperstimulation syndrome in Indian.

Slides:

Advertisements

Similar presentations

Validation of a prediction model for the follicle-stimulating hormone response dose in women with polycystic ovary syndrome Madelon van Wely, Ph.D.,

Advertisements

Yuqian Cui, M. D. , Ph. D. , Yuhua Shi, M. D. , Ph. D. , Linlin Cui, M

Age at menarche: a predictor of diminished ovarian function?

The relative effects of hormones and relationship factors on sexual function of women through the natural menopausal transition Lorraine Dennerstein,

The normal variabilities of the menstrual cycle

Michael M. Alper, M.D. Fertility and Sterility

Janet Kwee, M. D. , Roel Schats, M. D. , Ph. D. , Joseph McDonnell, M

Raoul Orvieto, M. D. , M. Sc. , Eduard Hod, M. D

Growth rates of ovarian follicles during natural menstrual cycles, oral contraception cycles, and ovarian stimulation cycles Angela R. Baerwald, Ph.D.,

Ethnicity as a determinant of ovarian reserve: differences in ovarian aging between Spanish and Indian women Carlos Iglesias, M.D., Manish Banker, M.D.,

Effect of the initiation of progesterone supplementation in in vitro fertilization–embryo transfer outcomes: a prospective randomized controlled trial

Surgical arrows should be identified on the cyst wall

Signe Altmäe, M. Sc. , Anneli Stavreus-Evers, Ph. D. , Jonatan R

Investigation of the human stem cell factor KIT ligand gene, KITLG, in women with 46,XX spontaneous premature ovarian failure Emily S. Hui, B.A., Ekemini.

CYP19 gene: a genetic modifier of polycystic ovary syndrome phenotype

Hakan Cakmak, M. D. , Audra Katz, R. N. , Marcelle I. Cedars, M. D

How old is too old? Challenges faced by clinicians concerning age cutoffs for patients undergoing in vitro fertilization Robert L. Klitzman, M.D. Fertility.

A Markov model of the cost-effectiveness of human-derived follicle-stimulating hormone (FSH) versus recombinant FSH using comparative clinical trial data

Improved monofollicular ovulation in anovulatory or oligo-ovulatory women after a low- dose step-up protocol with weekly increments of 25 international.

Anna-Helena Karypidis, M. D. , Torbjörn Söderström, M. D. , Ph. D

Differences in gene expression of granulosa cells from women undergoing controlled ovarian hyperstimulation with either recombinant follicle-stimulating.

Chao-Chin Hsu, M. D. , Ph. D. , Hsin-Chih Kuo, Ph. D

A microsatellite polymorphism (tttta)n in the promoter of the CYP11a gene in Chinese women with polycystic ovary syndrome Yong Wang, Ph.D., XiaoKe Wu,

Robert F. Casper, M.D. Fertility and Sterility

Ala16Val SOD2 polymorphism is associated with higher pregnancy rates in in vitro fertilization cycles José Ignacio Ruiz-Sanz, Ph.D., Igor Aurrekoetxea,

Influence of acupuncture stimulation on pregnancy rates for women undergoing embryo transfer Caroline Smith, Ph.D., Meaghan Coyle, B.Hlth.Sc. (Acup.),

Swapna S. Desai, Swati K. Achrekar, Smita R. Paranjape, Sadhana K

Serum luteinizing hormone levels are markedly increased and significantly correlated with Δ4-androstenedione levels in lean women with polycystic ovary.

A modest but significant effect of CGB5 gene promoter polymorphisms in modulating the risk of recurrent miscarriage Kristiina Rull, M.D., Ph.D., Ole.

Patients with severe ovarian hyperstimulation syndrome can be managed safely with aggressive outpatient transvaginal paracentesis Laura P. Smith, M.D.,

Tomer Singer, M. D. , David H. Barad, M. D. , M. S

Mohamed Fawzy, M. D. , Mohamed Y. AbdelRahman, M. D. , Mohamed H

Ovarian hyperstimulation secondary to ectopic secretion of follicle-stimulating hormone. Literature review prompted by a case Jorge Burgos, M.D., Patricia.

Treatment of Ovarian Hyperstimulation Syndrome Utilizing a Dopamine Agonist and Gonadotropin Releasing Hormone antagonist N. Rollene, M. Amols, S. Hudson,

Selection of viable spermatozoa from testicular biopsies: a comparative study between pentoxifylline and hypoosmotic swelling test Vijay Mangoli, Ph.D.,

Akanksha Mehta, M.D., Darius A. Paduch, M.D., Ph.D.

Effect of letrozole at 2. 5 mg or 5

Lower apoptosis rate in human cumulus cells after administration of recombinant luteinizing hormone to women undergoing ovarian stimulation for in vitro.

Treatment of male idiopathic infertility with recombinant human follicle-stimulating hormone: a prospective, controlled, randomized clinical study Carlo.

Hélio Sato, M. D. , Ph. D. , Naiara C. Nogueira-de-Souza, M. Sc. , Ph

Follicular-fluid neurotrophin levels in women undergoing assisted reproductive technology for different etiologies of infertility Erkan Buyuk, M.D.,

Endocrine gland–derived vascular endothelial growth factor concentrations in follicular fluid and serum may predict ovarian hyperstimulation syndrome.

Treatment of ovarian hyperstimulation syndrome using a dopamine agonist and gonadotropin releasing hormone antagonist: a case series Nanette L. Rollene,

P53 tumor suppressor factor, plasminogen activator inhibitor, and vascular endothelial growth factor gene polymorphisms and recurrent implantation failure

Cameron Gilbert, M. Sc. , Maria Valois, M. D. , FRCPC, Ph. D

Heterotopic autotransplantation of cryobanked human ovarian tissue as a strategy to restore ovarian function S.Samuel Kim, M.D., In-Tak Hwang, M.D.,

Pregnancy outcome in infertile patients with polycystic ovary syndrome who were treated with metformin Samuel S. Thatcher, M.D., Ph.D., Elizabeth M.

Isabelle Streuli, M. D. , Timothée Fraisse, M. D

Ovarian expression of markers associated with proliferation or apoptosis in women with diminished ovarian reserve Víctor Vital-Reyes, M.D., M.Sc., Cristina.

Association of maternal and fetal MTHFR A1298C polymorphism with the risk of pregnancy loss: a study of an Indian population and a meta-analysis Rohini.

Fertility and Sterility: an evaluation

Paolo Moghetti, M.D. Fertility and Sterility

Moderately elevated levels of basal follicle-stimulating hormone in young patients predict low ovarian response, but should not be used to disqualify.

Validation of a prediction model for the follicle-stimulating hormone response dose in women with polycystic ovary syndrome Madelon van Wely, Ph.D.,

Sedigheh Borna, M.D., Azita Nasery, M.D. Fertility and Sterility

Follicle-stimulating hormone receptor gene mutations are rare in Japanese women with premature ovarian failure and polycystic ovary syndrome Kenji Takakura,

Current evaluation of amenorrhea

Elizabeth X. Wu, M.Sc., Paloma Stanar, Sai Ma, Ph.D.

Keith A. Hansen, M. D. , Yueyi Zhang, M. D. , Robert Colver, M. D

Association of a polymorphism in the ornithine decarboxylase gene with male androgenetic alopecia Rachel A. Garton, MD, Amy J. McMichael, MD, Joel Sugarman,

Comparing anti-Müllerian hormone (AMH) and follicle-stimulating hormone (FSH) as predictors of ovarian function David H. Barad, M.D., M.S., Andrea Weghofer,

Cem Fiçicioǧlu, M. D. , Tayfun Kutlu, M. D. , Elif Baglam, M. D

In vitro sildenafil citrate use as a sperm motility stimulant

Soluble HLA-G in the peritoneal fluid of women with endometriosis

Randomized controlled trial: effects of acupuncture on pregnancy rates in women undergoing in vitro fertilization Irene Moy, M.D., Magdy P. Milad, M.D.,

Effect of methotrexate exposure on subsequent fertility in women undergoing controlled ovarian stimulation Janet F. McLaren, M.D., Richard O. Burney,

Ovarian follicular volume and follicular surface area are better indicators of follicular growth and maturation, respectively, than is follicular diameter

Chenming Xu, Ph. D. , Bingsen Xu, M. Sc. , Hefeng Huang, M. D

A prospective, comparative analysis of anti-Müllerian hormone, inhibin-B, and three- dimensional ultrasound determinants of ovarian reserve in the prediction.

A novel Arg615Ser mutation of androgen receptor DNA-binding domain in three 46,XY sisters with complete androgen insensitivity syndrome and bilateral.

Presentation transcript:

Follicle-stimulating hormone receptor polymorphism (Thr307Ala) is associated with variable ovarian response and ovarian hyperstimulation syndrome in Indian women Swati K. Achrekar, M.Sc., Deepak N. Modi, Ph.D., Sadhana K. Desai, M.D., Vijay S. Mangoli, Ph.D., Ranjana V. Mangoli, M.Sc., Smita D. Mahale, Ph.D. Fertility and Sterility Volume 91, Issue 2, Pages 432-439 (February 2009) DOI: 10.1016/j.fertnstert.2007.11.093 Copyright © 2009 American Society for Reproductive Medicine Terms and Conditions

Figure 1 (A) RFLP analysis of the Thr307Ala FSH receptor polymorphism. Lane 1: PCR product of external PCR using primer set as mentioned in Methodology (447 bp). Lane 2: PCR product using nested primers as in Reference 24 (364 bp). Lane 3: PhiX174 DNA Hinf I ladder. Lanes 4–10: digested PCR products showing the polymorphism. Lanes 4, 6, 7, and 9: two fragments, 364 bp and 328 bp, indicates heterozygous TA. Lanes 5 and 8: 364-bp fragment for homozygous T. Lane 10: 328-bp fragment for homozygous A. (B) Electropherogram showing the polymorphism at position 307. TT showing homozygous T allele (arrow), TA showing heterozygosity (arrow), and AA showing homozygous A allele (arrow). Fertility and Sterility 2009 91, 432-439DOI: (10.1016/j.fertnstert.2007.11.093) Copyright © 2009 American Society for Reproductive Medicine Terms and Conditions

Figure 2 (A) RFLP analysis of the Asn680Ser FSH receptor polymorphism. Lane 1: phiX174 DNA Hinf I ladder. Lane 2: undigested PCR product of 520 bp. Lanes 3–7: digested PCR products showing the polymorphism. Lanes 3 and 5: two fragments of 413 bp and 107 bp for homozygous S. Lane 4: 520-bp fragment for homozygous N. Lanes 6 and 7: three fragments of 520 bp, 413 bp, and 107 bp for heterozygous NS. (B) Electropherogram showing the polymorphism at position 680. NN showing homozygous N allele (arrow), NS showing heterozygosity (arrow), and SS showing homozygous S allele (arrow). Fertility and Sterility 2009 91, 432-439DOI: (10.1016/j.fertnstert.2007.11.093) Copyright © 2009 American Society for Reproductive Medicine Terms and Conditions

Figure 3 Distribution of the FSH receptor genotypes at position 307 (A) and position 680 (B) in controls and subjects undergoing ART. Fertility and Sterility 2009 91, 432-439DOI: (10.1016/j.fertnstert.2007.11.093) Copyright © 2009 American Society for Reproductive Medicine Terms and Conditions