Carotid endarterectomy impairs blood pressure homeostasis by reducing the physiologic baroreflex reserve S.A. Reza Nouraei, MA MBBChir, Pippa G. Al-Rawi,

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Carotid endarterectomy impairs blood pressure homeostasis by reducing the physiologic baroreflex reserve S.A. Reza Nouraei, MA MBBChir, Pippa G. Al-Rawi, BSc, Dominique Sigaudo-Roussel, PhD, Dino A. Giussani, PhD, Michael E. Gaunt, MD(Dist) Journal of Vascular Surgery Volume 41, Issue 4, Pages 631-637 (April 2005) DOI: 10.1016/j.jvs.2005.01.009 Copyright © 2005 The Society for Vascular Surgery Terms and Conditions

Fig 1 The overall hemodynamic response to carotid endarterectomy in diseased (n = 23) and control (n = 37) groups. Results are mean ± SE. BP, Blood pressure; HR, heart rate. Results are mean ± SE. Journal of Vascular Surgery 2005 41, 631-637DOI: (10.1016/j.jvs.2005.01.009) Copyright © 2005 The Society for Vascular Surgery Terms and Conditions

Fig 2 Differential response blood pressure (BP) and heart rate of patients with normal (control, n = 37) and diseased (n = 23) contralateral carotid artery to carotid endarterectomy. Results are mean ± SE. Journal of Vascular Surgery 2005 41, 631-637DOI: (10.1016/j.jvs.2005.01.009) Copyright © 2005 The Society for Vascular Surgery Terms and Conditions

Fig 3 A, Intraluminal rub test before carotid endarterectomy led to a significant hypotensive response in patients with diseased contralateral carotid artery (n = 23) but not in patients with normal (control, n = 37) contralateral carotid. B, This response was obliterated after carotid endarterectomy. Results are mean ± SE. Journal of Vascular Surgery 2005 41, 631-637DOI: (10.1016/j.jvs.2005.01.009) Copyright © 2005 The Society for Vascular Surgery Terms and Conditions

Fig 4 A, Carotid endarterectomy led to a significant hypertensive resetting of the baroreflex operating set point, more significantly affecting patients with contralateral carotid artery disease. B, Peak spontaneous baroreflex sensitivity was significantly reduced in both groups after carotid endarterectomy, but the difference between the two groups did not reach statistical significance (diseased, n = 23; control, n = 37). Results are mean ± SE. Journal of Vascular Surgery 2005 41, 631-637DOI: (10.1016/j.jvs.2005.01.009) Copyright © 2005 The Society for Vascular Surgery Terms and Conditions