Stimulation on Demand: Closing the Loop on Deep Brain Stimulation

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Stimulation on Demand: Closing the Loop on Deep Brain Stimulation Fernando J. Santos, Rui M. Costa, Fatuel Tecuapetla Neuron Volume 72, Issue 2, Pages 197-198 (October 2011) DOI: 10.1016/j.neuron.2011.10.004 Copyright © 2011 Elsevier Inc. Terms and Conditions

Figure 1 Illustration of an Open-Loop and an Adaptive Closed-Loop Deep Brain Stimulation (DBS) Paradigm (A) Standard “open-loop” high-frequency (130 Hz) DBS consists of continuous stimulation of a target structure (i.e., internal segment of the globus pallidum, GPi) through an implanted electrode. (B) Adaptive “closed-loop” DBS consists of using the online activity of a reference structure (i.e., primary motor cortex, M1) as a trigger for stimulation of the target structure (i.e., GPi) after a certain delay (i.e., 80 ms). This results in a lower frequency and more irregular pattern of stimulation and promotes a substantial reduction of Parkinsonian akinesia compared with standard “open-loop” DBS protocols, by adapting the stimulation to the dynamics of cortico-basal ganglia networks. Neuron 2011 72, 197-198DOI: (10.1016/j.neuron.2011.10.004) Copyright © 2011 Elsevier Inc. Terms and Conditions