Review from yesterday Non-Specific Defenses Specific Defenses 1st Line: Skin Tears, Mucus, Saliva Sweat 2nd Line: Inflammatory Response Fever Against Viruses: Interferon Specific Defenses Humoral Immunity B-Cells Antibodies Cell-Mediated Immunity…

Specific Defenses Cell-Mediated Immunity Killer T Cells: The HIT MAN! Kills infected Body cells

Cell-Mediated Immune Response “Calling out the hitman – Killer T!” Pacman the boss eats pathogen and finds ID T cell binds to activated macrophage to read the antigen Helper T Cell tells Killer T cell who to look for Killer T Cell checks ID Helper T Cell “the hitman” picks up ID If ID matches, Killer T eliminate the bacteria Antigens are displayed on surface of macrophage Killer T cells bind to infected cells, disrupting their cell membranes and destroying them

Cell-Mediated Immunity: Worksheet Pathogen enters body Macrophage eats pathogen Displays Antigen on its surface Helper T cell gets antigen ID from Macrophage Helper T cell tells Killer T cells what antigen to look for Killer T cells kill any cell displaying antigen (including infected body cells) Cell dies Suppressor T cells tell Killer T cells to stop killing when pathogen is gone

Acquired Immunity

Acquired Immunity 2 Kinds: Active Immunity Passive Immunity You make antibodies Passive Immunity Another person or thing’s antibodies are put into your body

Active Immunity When immunity comes from your body making antibodies for a pathogen. Once the antibodies are present, you will not get sick from that pathogen again. Permanent Immunity

Active Immunity 2 ways to get Active Immunity Get sick, get antibodies Vaccination Purposefully introduce a weakened pathogen into your body You do not get sick Your body makes antibodies for that pathogen

Passive Immunity When immunity comes from someone or something else’s antibodies being introduced into the body Provides TEMPORARY immunity Your body will eventually destroy the foreign antibodies.

Passive Immunity Get a shot of antibodies (vaccine) before traveling to a foreign country for a short period of time. After Rabies exposure Mothers give their antibodies to baby through breast milk

In Review 2 types of Acquired Immunity Active Passive Your body makes antibodies Get sick Get vaccine of weakened pathogen PERMANENT Passive Put someone/thing else’s antibodies into your body Mother’s breastmilk to baby Vaccine of antibodies TEMPORARY