Figure 6 The hexosamine biosynthetic pathway (HBP)

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Figure 6 The hexosamine biosynthetic pathway (HBP) Figure 6 | The hexosamine biosynthetic pathway (HBP). Enzymes of the HBP pathway metabolize glucose to produce UDP- N-acetylglucosamine (GlcNAc). UDP-GlcNAc serves as a major sugar donor for O-GlcNAcylation and for classical N-linked and O-linked glycosylation. O-GlcNAc transferase (OGT) catalyses the transfer of GlcNAc from the sugar donor UDP-GlcNAc to the hydroxyl groups of serine and/or threonine residues. O-GlcNAcase (OGA) carries out the reverse reaction and hydrolyses the sugar from proteins. Expression of the rate-limiting enzyme UDP N-acetylhexosamine pyrophosphorylase is upregulated in prostate cancer cells and has been linked to disease progression. Munkley, J. et al. (2016) The role of glycans in the development and progression of prostate cancer Nat. Rev. Urol. doi:10.1038/nrurol.2016.65