Adult (2- to 4-mo-old) Nlgn3y/– mice modify the social behavior of their littermates. Adult (2- to 4-mo-old) Nlgn3y/– mice modify the social behavior of.

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Adult (2- to 4-mo-old) Nlgn3y/– mice modify the social behavior of their littermates. Adult (2- to 4-mo-old) Nlgn3y/– mice modify the social behavior of their littermates. A, Nlgn3y/+ and Nlgn3y/– mice from SGH and Nlgn3y/– mice from MGH showed increased interest in social odors compared with water, whereas this increased interest was absent in Nlgn3y/+ mice from MGH. Note that Nlgn3y/+ and Nlgn3y/– mice from SGH spent more time sniffing the social odor compared with Nlgn3y/+ and Nlgn3y/– mice from MGH, respectively. B, Nlgn3y/+PvalbCre/+ and Nlgn3y/–PvalbCre/+ mice showed an increased interest for social odors compared with Nlgn3y/+ and Nlgn3y/– mice from MGH. C, Western blot analysis shows a ratio of re-expression of 0.7 in the cerebellum, 0.15 in the brainstem, 0.1 in the striatum, 0.1 in the thalamus, and 0.04 in the cortex and no re-expression in the hippocampus. Note that the upper band in the brainstem Nlgn3y/– sample is most likely unspecific, as it appears in protein samples from Nlgn3y/– mice. D, Nlgn3y/– and Nlgn3y/+ mice from MGH lost more frequently against an unfamiliar submissive mouse compared with Nlgn3y/–PvalbCre/+ and Nlgn3y/+PvalbCre/+ mice. No difference in the percentage of wins against an unfamiliar submissive male was found in the tube test between Nlgn3y/+PvalbCre/+ and Nlgn3y/–PvalbCre/+ mice. Note that Nlgn3y/+ and Nlgn3y/– mice from MGH data are replotted from Fig. 3A. The dotted line represents the mean percentage of wins for Nlgn3y/+ mice from SGH. E, Nlgn3y/– mice from MGH and Nlgn3y/–PvalbCre/+ mice spent less time calling a female in estrus than Nlgn3y/+ mice from MGH and Nlgn3y/+PvalbCre/+mice, respectively. The dotted line represents the mean time sent calling for Nlgn3y/+ mice from SGH, replotted from Fig. 3B. Values are represented as mean ± SEM. Statistical significance was tested by two-way ANOVA repeated-measures (A), two-way ANOVA (B, D, and E), and post hoc Sidak’s multiple comparison test. *P < 0.05; **P < 0.001; ****P < 0.0001. Shireene Kalbassi et al. eNeuro 2017;4:ENEURO.0145-17.2017 ©2017 by Society for Neuroscience