Anemia and retinal function in a mouse model of acute colitis

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Anemia and retinal function in a mouse model of acute colitis Megan N. Watts, Norman R. Harris Pathophysiology Volume 21, Issue 4, Pages 301-308 (November 2014) DOI: 10.1016/j.pathophys.2014.08.001 Copyright © 2014 Elsevier B.V. Terms and Conditions

Fig. 1 Example of electroretinogram (ERG) signals from a control mouse and a mouse given DSS drinking water. The double arrows indicate the approximate a-wave and b-wave amplitudes, and the dotted lines connect the oscillatory potentials (OPs) between the two waveforms. The slant in the dashed lines indicates delayed formation of the OPs in the DSS waveform compared to the control. Pathophysiology 2014 21, 301-308DOI: (10.1016/j.pathophys.2014.08.001) Copyright © 2014 Elsevier B.V. Terms and Conditions

Fig. 2 Colon weight per unit length (A), colon length (B), colon weight (C), and body weight (D) in the three groups of mice (N=13, control; N=21, DSS; N=12, DSS+RBC). The body weight values were recorded on the first and final days of the 6-day protocol. ***P<0.001 versus controls. Pathophysiology 2014 21, 301-308DOI: (10.1016/j.pathophys.2014.08.001) Copyright © 2014 Elsevier B.V. Terms and Conditions

Fig. 3 Correlative relationships between ERG parameters and values of hematocrit. (A) a-wave amplitude, (B) b-wave amplitude, (C) OP amplitudes, (D) a-wave implicit times, (E) b-wave implicit times, and (F) OP implicit times. The regression slope in panel (F) was still statistically significant (R2=0.30, P=0.0012) even without the inclusion of the two highest implicit times. In each panel, the solid circles are from the Untreated DSS mice and the open circles are from the control mice. Pathophysiology 2014 21, 301-308DOI: (10.1016/j.pathophys.2014.08.001) Copyright © 2014 Elsevier B.V. Terms and Conditions

Fig. 4 (A) Pre-infusion and post-experiment hematocrit values in all three groups of mice (N=13, control; N=21, DSS; N=12, DSS+RBC), where saline alone was infused into the untreated control and DSS mice. (B) Pre-infusion and post-experiment hematocrit values in the mice infused with RBCs. In panel (A), *P<0.05 and ***P<0.001 versus controls, and +++P<0.001 versus DSS. Pathophysiology 2014 21, 301-308DOI: (10.1016/j.pathophys.2014.08.001) Copyright © 2014 Elsevier B.V. Terms and Conditions

Fig. 5 Retinal function (ERG) parameters, including the a-wave amplitudes (A), b-wave amplitudes (B), oscillatory potential amplitudes (C), and associated implicit times (D–F) for the three groups of mice (N=13, control; N=21, DSS; N=12, DSS+RBC). The data from the first four OPs beginning on the ascending b-wave were summed for (C) and (F). *P<0.05 versus controls; +P<0.05 versus DSS+RBC. Pathophysiology 2014 21, 301-308DOI: (10.1016/j.pathophys.2014.08.001) Copyright © 2014 Elsevier B.V. Terms and Conditions