Does the addition of time-lapse morphokinetics in the selection of embryos for transfer improve pregnancy rates? A randomized controlled trial Linnea.

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Presentation transcript:

Does the addition of time-lapse morphokinetics in the selection of embryos for transfer improve pregnancy rates? A randomized controlled trial Linnea R. Goodman, M.D., Jeffrey Goldberg, M.D., Tommaso Falcone, M.D., Cynthia Austin, M.D., Nina Desai, Ph.D., H.C.L.D. Fertility and Sterility Volume 105, Issue 2, Pages 275-285.e10 (February 2016) DOI: 10.1016/j.fertnstert.2015.10.013 Copyright © 2016 American Society for Reproductive Medicine Terms and Conditions

Figure 1 Flow chart of inclusion. PGS/PGD = preimplantation genetic screening/diagnosis. Fertility and Sterility 2016 105, 275-285.e10DOI: (10.1016/j.fertnstert.2015.10.013) Copyright © 2016 American Society for Reproductive Medicine Terms and Conditions

Figure 2 Embryo growth and development over time. The top of the figure depicts the conventional screening standard viewing points ± 1 hour (HPI = hours after insemination). Time-lapse monitoring occurred continuously. Dysmorphisms that were evaluated are pictured at the bottom. Established time frames incorporated into the morphokinetic score (cc2, s2, t5, s3, and tSB) are shown. Fertility and Sterility 2016 105, 275-285.e10DOI: (10.1016/j.fertnstert.2015.10.013) Copyright © 2016 American Society for Reproductive Medicine Terms and Conditions

Figure 3 Blastocyst morphokinetic scores between transferred, cryopreserved, and discarded embryos in time-lapse monitoring (TLM) and conventional screening (CS) groups. Scores of transferred blastocysts were significantly higher in the TLM group, but there was no difference in scores of cryopreserved embryos between groups. *P=.01: significant difference in score between transferred blastocysts in TLM vs. CS group. **No significant difference in score between frozen blastocysts in TLM vs. CS group. ***No significant difference in score between discarded embryos in TLM vs. CS group. Fertility and Sterility 2016 105, 275-285.e10DOI: (10.1016/j.fertnstert.2015.10.013) Copyright © 2016 American Society for Reproductive Medicine Terms and Conditions

Supplemental Figure 1 The percentage of embryos completing the specified cell divisions at a given time are depicted by implantation status. There was no difference in timing of t2 or t5 between embryos that implanted and those that did not. There were significantly more embryos that reached tSB by 100 hours that implanted than those that did not (76% vs. 54%; P<.01). Fertility and Sterility 2016 105, 275-285.e10DOI: (10.1016/j.fertnstert.2015.10.013) Copyright © 2016 American Society for Reproductive Medicine Terms and Conditions

Supplemental Figure 2 Time to start of blastulation as a predictor of implantation. Fertility and Sterility 2016 105, 275-285.e10DOI: (10.1016/j.fertnstert.2015.10.013) Copyright © 2016 American Society for Reproductive Medicine Terms and Conditions