Volume 13, Issue 11, Pages e509-e517 (November 2012)

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Presentation transcript:

Volume 13, Issue 11, Pages e509-e517 (November 2012) Do low-grade and low-volume prostate cancers bear the hallmarks of malignancy? Dr Hashim Uddin Ahmed, MRCS, Manit Arya, FRCS, Alex Freeman, FRCPath, Prof Mark Emberton, FRCS The Lancet Oncology Volume 13, Issue 11, Pages e509-e517 (November 2012) DOI: 10.1016/S1470-2045(12)70388-1 Copyright © 2012 Elsevier Ltd Terms and Conditions

Figure 1 Hallmarks of cancer as applied to the index and secondary lesions in prostate cancer The Lancet Oncology 2012 13, e509-e517DOI: (10.1016/S1470-2045(12)70388-1) Copyright © 2012 Elsevier Ltd Terms and Conditions

Figure 2 Gleason grade patterns for prostate cancer lesions (A) Gleason grade 1 (arrows outline an individual prostate acinus; original magnification ×40. (B) Gleason grade 2 (original magnification ×40). (C) Gleason grade 3 (arrows show a small amount of individual cell infiltration into surrounding stroma; original magnification ×100). (D) Gleason grade 4 (increased stromal invasion; white arrows show some areas of gland fusion and poorly defined lumens; green arrow shows one of a few areas in which Gleason pattern 3 is present; original magnification ×40). (E) Gleason grade 5 (solid sheets of cells with no glandular structures and poorly differentiated cells; original magnification ×100). L=lumen. The Lancet Oncology 2012 13, e509-e517DOI: (10.1016/S1470-2045(12)70388-1) Copyright © 2012 Elsevier Ltd Terms and Conditions