Utility of serum antibodies in determining clinical course in pediatric Crohn’s disease  Barbara Desir, Devendra K Amre, Shou-en Lu, Pamela Ohman-strickland, Marla Dubinsky, Rachel Fisher, Ernest G Seidman  Clinical Gastroenterology and Hepatology  Volume 2, Issue 2, Pages 139-146 (February 2004) DOI: 10.1016/S1542-3565(03)00321-5

Figure 1 Pattern of ASCA-IgA titers during disease course. The LOESS smoothing curve fitted to the scatterplot indicates that on average, there is no change in titer levels over time. Levels seem to increase after 6 years since diagnosis; however, there were few subjects that were followed up for more than 6 years. Clinical Gastroenterology and Hepatology 2004 2, 139-146DOI: (10.1016/S1542-3565(03)00321-5)

Figure 2 Pattern of ASCA-IgG titers during disease course. The LOESS smoothing curve fitted to the data indicates that on average, there is no change in titer levels over time. However, inter-individual variation in baseline (close to diagnosis) titer levels and pattern over time is evident. Clinical Gastroenterology and Hepatology 2004 2, 139-146DOI: (10.1016/S1542-3565(03)00321-5)

Figure 3 Pattern of p-ANCA titers during disease course. The LOESS smoothing curve fitted to the data indicates that on average, the antibody levels are pretty constant over time. Inter-individual variations in the patterns over time are observed. Clinical Gastroenterology and Hepatology 2004 2, 139-146DOI: (10.1016/S1542-3565(03)00321-5)