Subclinical granulomas in benign skin lesions heralding the onset of BRAF and MEK inhibitor–associated granulomatous dermatitis in a patient with metastatic.

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Presentation transcript:

Subclinical granulomas in benign skin lesions heralding the onset of BRAF and MEK inhibitor–associated granulomatous dermatitis in a patient with metastatic melanoma Abraham M. Korman, MD, Mahrukh S. Nisar, MD, Stephen C. Somach, MD JAAD Case Reports Volume 4, Issue 7, Pages 722-724 (August 2018) DOI: 10.1016/j.jdcr.2018.05.011 Copyright © 2018 American Academy of Dermatology, Inc. Terms and Conditions

Fig 1 Punch biopsy specimen of a blue gray macule prepared with hematoxylin-eosin stain (H&E) shows epithelioid granulomas in proximity to a blue nevus. JAAD Case Reports 2018 4, 722-724DOI: (10.1016/j.jdcr.2018.05.011) Copyright © 2018 American Academy of Dermatology, Inc. Terms and Conditions

Fig 2 Shave biopsy specimen of a tan macule from the left forearm prepared with H&E shows a solar lentigo with an associated epithelioid granuloma (arrow). JAAD Case Reports 2018 4, 722-724DOI: (10.1016/j.jdcr.2018.05.011) Copyright © 2018 American Academy of Dermatology, Inc. Terms and Conditions

Fig 3 Shave biopsy of a thin pink scaly plaque from the right forearm prepared with H&E shows an interstitial granulomatous dermatitis with areas of palisading and mucin deposition resembling granuloma annulare. JAAD Case Reports 2018 4, 722-724DOI: (10.1016/j.jdcr.2018.05.011) Copyright © 2018 American Academy of Dermatology, Inc. Terms and Conditions

Fig 4 Shave biopsy specimen of an erythematous papule on the right toe prepared with H&E shows superficial dermal epithelioid granulomas. JAAD Case Reports 2018 4, 722-724DOI: (10.1016/j.jdcr.2018.05.011) Copyright © 2018 American Academy of Dermatology, Inc. Terms and Conditions