Cohesin and the Maternal Age Effect

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Cohesin and the Maternal Age Effect William D. Gilliland, R. Scott Hawley Cell Volume 123, Issue 3, Pages 371-373 (November 2005) DOI: 10.1016/j.cell.2005.10.018 Copyright © 2005 Elsevier Inc. Terms and Conditions

Figure 1 The Maternal Age Effect in Humans and Mice The maternal age effect on nondisjunction of meiotic chromosomes (as measured by trisomy production) in humans (top panel) is compared with age-dependent defects observed in SMC1β-deficient female mice (bottom panel). The graph of the frequency of human trisomies with advancing maternal age is modified from Hassold and Hunt (2001). The percentage of homologs present as single chromatids in mice lacking SMC1β, which reflects the failure of sister-chromatid cohesion, was modified from Hodges et al. (2005). Cell 2005 123, 371-373DOI: (10.1016/j.cell.2005.10.018) Copyright © 2005 Elsevier Inc. Terms and Conditions