If triglycerides matter, why do they matter?

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Presentation transcript:

If triglycerides matter, why do they matter? Allan D. Sniderman  Journal of Indian College of Cardiology  Volume 6, Pages S26-S31 (May 2016) DOI: 10.1016/j.jicc.2015.05.008 Copyright © 2015 Terms and Conditions

Fig. 1 This figure illustrates the different apoB lipoprotein particles. Note these differ as to which form of apoB is present-apoB48 vs apoB100 and size. Note also that LDL particles differ in size because they differ in cholesterol content. Journal of Indian College of Cardiology 2016 6, S26-S31DOI: (10.1016/j.jicc.2015.05.008) Copyright © 2015 Terms and Conditions

Fig. 2 Remnant lipoprotein disorder. Note the massive accumulation of remnant chylomicron and VLDL particles and the decreased number of LDL particles. Journal of Indian College of Cardiology 2016 6, S26-S31DOI: (10.1016/j.jicc.2015.05.008) Copyright © 2015 Terms and Conditions

Fig. 3 A. HyperTG NormoapoB: Note the triglyceride-enriched VLDL particle. Sometimes VLDL particle number can be increased because the clearance rate is reduced. A normal number of LDL particles are present, most of which are smaller than average because their cholesterol content is reduced, B. HyperTG HyperapoB: VLDL particle number is increased as is LDL particle number. Journal of Indian College of Cardiology 2016 6, S26-S31DOI: (10.1016/j.jicc.2015.05.008) Copyright © 2015 Terms and Conditions

Fig. 4 Results from the Quebec Cardiovascular Study that demonstrate it is the increased LDL particle number that explains why cardiovascular risk is markedly increased in HyperTG HyperapoB compared to HyperTG NormoapoB. Journal of Indian College of Cardiology 2016 6, S26-S31DOI: (10.1016/j.jicc.2015.05.008) Copyright © 2015 Terms and Conditions