Jonathan I. Silverberg, MD, PhD, MPH, Nanette B. Silverberg, MD

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Serum homocysteine as a biomarker of vitiligo vulgaris severity: A pilot study Jonathan I. Silverberg, MD, PhD, MPH, Nanette B. Silverberg, MD Journal of the American Academy of Dermatology Volume 64, Issue 2, Pages 445-447 (February 2011) DOI: 10.1016/j.jaad.2010.08.025 Copyright © 2010 American Academy of Dermatology, Inc. Terms and Conditions

Fig 1 Association between serum homocysteine and vitamin B12 levels. Serum homocysteine levels are associated inversely with serum vitamin B12. Linear regression model was constructed both as parsimonious models and confounding models including age, gender, ethnicity, serum vitamin B12 levels, and supplementation with oral vitamin B12 and folic acid. Outliers were excluded from statistical analysis and are indicated as open circles. Regression coefficient and P value for the confounding model are presented above. Journal of the American Academy of Dermatology 2011 64, 445-447DOI: (10.1016/j.jaad.2010.08.025) Copyright © 2010 American Academy of Dermatology, Inc. Terms and Conditions

Fig 2 Association between vitiligo extent and serum homocysteine levels. A, Body surface area, (B) number of body parts involved, (C) bilaterality of lesions, but not (D) distribution of lesions (dependent variables) are associated with serum homocysteine levels (independent variables). Linear regression models were constructed both as parsimonious models and as confounding models including age, gender, ethnicity, serum vitamin B12 levels, and supplementation with oral vitamin B12 and folic acid. Outliers were excluded from statistical analysis and are indicated as open circles. Regression coefficients for confounding models and P values are presented above, except for panel C, where results of parsimonious model are presented. Journal of the American Academy of Dermatology 2011 64, 445-447DOI: (10.1016/j.jaad.2010.08.025) Copyright © 2010 American Academy of Dermatology, Inc. Terms and Conditions