Brain MRI scans for the patient.

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Brain MRI scans for the patient. Brain MRI scans for the patient. (A,B) Brain MRI (fat-suppressed T1-weighted contrast MRI) before the initiation of osimertinib showed leptomeningeal enhancement, multiple nodular deposits in the subarachnoid space, and multiple nodules in the cerebral parenchyma. (C,D) A scan performed 7 weeks after the initiation of osimertinib revealed shrinkage of the multiple nodular deposits (arrows). Hitomi Sakai et al. ESMO Open 2017;2:e000104 Copyright © European Society for Medical Oncology. All rights reserved.