Microbial Killing: Oxidants, Proteases and Ions

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Microbial Killing: Oxidants, Proteases and Ions Rene E Harrison, Nicolas Touret, Sergio Grinstein  Current Biology  Volume 12, Issue 10, Pages R357-R359 (May 2002) DOI: 10.1016/S0960-9822(02)00859-X

Fig. 1 Ionic and chemical correlates of the respiratory burst in neutrophil phagosomes. (A) The engulfment of a microorganism triggers the activation of the NADPH oxidase, which results in the vectorial transfer of electrons from NADPH into the phagosome, leading to the development of a transmembrane potential (inside negative) and the reduction of O2, generating superoxide (O2−). The membrane potential drives H+ and K+ ions into the lumen via conductive pathways; H+ ions are also pumped in by the V-ATPase. (B) Superoxide is a substrate for superoxide dismutase (SOD), which catalyzes the formation of hydrogen peroxide. Peroxide can be converted to hypochlorous acid (HOCl) by myeloperoxidase (MPO). HOCl in turn can generate secondary reactive oxidants including hydroxyl radical (HO.) and singlet oxygen (1O2). Note that H+ ions are consumed in the dismutation of superoxide and in HOCl formation. Superoxide can also combine with nitric oxide to form peroxinitrite. Current Biology 2002 12, R357-R359DOI: (10.1016/S0960-9822(02)00859-X)

Fig. 2 Models for the release of granule contents into the phagosome. (A) K+ ions entering from the phagosomal lumen via the fusion pore leads to the release of proteases and myeloperoxidase from the granule matrix. According to Reeves et al.[8], hypertonic concentration of K+ in the lumen is required for this release. (B) Reactive oxygen species (ROS) may enter the granule and contribute to release of contents. (C) K+/H+ ions entering across channels in the granule membrane contribute to release of contents. Current Biology 2002 12, R357-R359DOI: (10.1016/S0960-9822(02)00859-X)