Lactate Wreaks Havoc on Tumor-Infiltrating T and NK Cells Kristen E.N. Scott, John L. Cleveland  Cell Metabolism  Volume 24, Issue 5, Pages 649-650 (November 2016) DOI: 10.1016/j.cmet.2016.10.015 Copyright © 2016 Elsevier Inc. Terms and Conditions

Figure 1 Lactate Lowers the Boom on Immune Surveillance Left half: highly glycolytic tumor cells express high levels of LDHA and efflux lactic acid (orange squares) acidifying (yellow) the tumor milieu and compromising activation of CD8+ T and NK cells and their competition for nutrients, such as glucose (blue squares) or amino acids (e.g., arginine, green squares). Right half: tumor cells with low levels of LDHA are poor competitors for nutrients in the tumor microenvironment, allowing effective recruitment and activation of immune cells, their release of IFNγ (black dots) that further drives immune cell activation, and tumor cell killing. Cell Metabolism 2016 24, 649-650DOI: (10.1016/j.cmet.2016.10.015) Copyright © 2016 Elsevier Inc. Terms and Conditions