Chondroprotective effects of high-molecular-weight cross-linked hyaluronic acid in a rabbit knee osteoarthritis model S. Elmorsy, T. Funakoshi, F. Sasazawa,

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Presentation transcript:

Chondroprotective effects of high-molecular-weight cross-linked hyaluronic acid in a rabbit knee osteoarthritis model S. Elmorsy, T. Funakoshi, F. Sasazawa, M. Todoh, S. Tadano, N. Iwasaki Osteoarthritis and Cartilage Volume 22, Issue 1, Pages 121-127 (January 2014) DOI: 10.1016/j.joca.2013.10.005 Copyright © 2013 Osteoarthritis Research Society International Terms and Conditions

Fig. 1 Illustration of the pendulum friction tester used in this study. The friction coefficient μ was calculated using the equation μ = LΔθ/4r, where r is the radius of the rabbit femoral condyle, L is the distance between the pendulum's center of gravity and center of rotation, and Δθ is the average decrease in the amplitude of the pendulum swing per cycle. Osteoarthritis and Cartilage 2014 22, 121-127DOI: (10.1016/j.joca.2013.10.005) Copyright © 2013 Osteoarthritis Research Society International Terms and Conditions

Fig. 2 Macroscopic assessment of the medial femoral condyles from each group 8 weeks after surgery. Cartilage degeneration in the HA600 group was generally less severe than that in either the NS or HA80 group (n = 5 per group). Osteoarthritis and Cartilage 2014 22, 121-127DOI: (10.1016/j.joca.2013.10.005) Copyright © 2013 Osteoarthritis Research Society International Terms and Conditions

Fig. 3 Histological findings (Safranin-O stain) of the medial femoral condyles from each group 8 weeks after surgery. NS (A, D); HA80 (B, E); HA600 (C, F); sham (G, I); normal knee that had not been operated on (H, J). Osteoarthritis and Cartilage 2014 22, 121-127DOI: (10.1016/j.joca.2013.10.005) Copyright © 2013 Osteoarthritis Research Society International Terms and Conditions

Fig. 4 Mean values for the friction coefficients obtained with the pendulum friction test. Error bars represent the 95% CIs (n = 5 per group). *P = 0.002 of HA600 vs the NS control. Osteoarthritis and Cartilage 2014 22, 121-127DOI: (10.1016/j.joca.2013.10.005) Copyright © 2013 Osteoarthritis Research Society International Terms and Conditions