B. Haelewyn, A. Yvon, J. L. Hanouz, E. T. MacKenzie, P. Ducouret, J. L

Slides:

Advertisements

Similar presentations

Fig. 2. Post-treatment with isoflurane reduced infarct volume

Advertisements

Xenon: no stranger to anaesthesia

Halothane potentiates the effect of methamphetamine and nomifensine on extracellular dopamine levels in rat striatum: a microdialysis study Y.U. Adachi,

N.P. Talbot, P.A. Robbins, K.L. Dorrington

C Dualé, C Frey, F Bolandard, A Barrière, P Schoeffler

Presynaptic inhibition of the release of multiple major central nervous system neurotransmitter types by the inhaled anaesthetic isoflurane R.I. Westphalen,

Type of anaesthesia and patient quality of recovery: a randomized trial comparing propofol–remifentanil total i.v. anaesthesia with desflurane anaesthesia

Anaesthetic preconditioning but not postconditioning prevents early activation of the deleterious cardiac remodelling programme: evidence of opposing.

Tracheal intubation using a Macintosh laryngoscope or a GlideScope® in 15 patients with cervical spine immobilization F Agrò, G Barzoi, F Montecchia

L. Tong, M. Cai, Y. Huang, H. Zhang, B. Su, Z. Li, H. Dong

Dexmedetomidine-mediated neuroprotection against sevoflurane-induced neurotoxicity extends to several brain regions in neonatal rats J.F. Perez-Zoghbi,

L. Pain, A. Launoy, N. Fouquet, P. Oberling

A different use of visual analytic techniques in anaesthetics

M. Naguib, D. L. Hammond, P. G. Schmid III, M. T. Baker, J. Cutkomp, L

Effects of dexamethasone on clinical course, C-reactive protein, S100B protein and von Willebrand factor antigen after paediatric cardiac surgery L Lindberg,

J. Ahonen, R. Jokela, K. Uutela, M. Huiku

R.W.D. Nickalls, W.W. Mapleson British Journal of Anaesthesia

Prediction of volatile anaesthetic solubility in blood and priming fluids for extracorporeal circulation R.-G. Yu, J.-X. Zhou, J Liu British Journal.

Recent advances in gas exchange measurement in intensive care patients

Comparison of remifentanil and alfentanil during anaesthesia for patients undergoing direct laryngoscopy without intubation E. Wiel, M. Davette, L. Carpentier,

M.A. Olympio, R. Whelan, R.P.A. Ford, I.C.M. Saunders

Time course of inhaled anaesthetic drug delivery using a new multifunctional closed- circuit anaesthesia ventilator. In vitro comparison with a classical.

Modification of tracheal tubes

Apparent diffusion coefficient mapping predicts mortality and outcome in rats with intracerebral haemodynamic disturbance: potential role of intraoperative.

Comparison of morphine-6-glucuronide and morphine on respiratory depressant and antinociceptive responses in wild type and μ-opioid receptor deficient.

A. Absalom, D. Amutike, A. Lal, M. White, G.N.C. Kenny

Effect of continuous low-dose intravenous diltiazem on epidural fentanyl analgesia after lower abdominal surgery K. Nitahara, M. Matsunaga, K. Katori,

D.H.J. Davis, M. Oliver, A.J. Byrne British Journal of Anaesthesia

Timing of xenon-induced delayed postconditioning to protect against spinal cord ischaemia–reperfusion injury in rats Y.W. Yang, W.P. Cheng, J.K. Lu,

M. Iwata, S. Inoue, M. Kawaguchi, H. Furuya

Development of acute tolerance to the EEG effect of propofol in rats†

Block of the sacral segments in lumbar epidural anaesthesia

Faster wash-out and recovery for desflurane vs sevoflurane in morbidly obese patients when no premedication is used L. La Colla, A. Albertin, G. La Colla,

Balancing paediatric anaesthesia: preclinical insights into analgesia, hypnosis, neuroprotection, and neurotoxicity R.D. Sanders, D. Ma, P. Brooks, M.

Digital ischaemia after ulnar artery cannulation

B. McNamara, J. Ray, D. Menon, S. Boniface

Expertise in practice: an ethnographic study exploring acquisition and use of knowledge in anaesthesia A. Smith, D. Goodwin, M. Mort, C. Pope British.

I.V. infusion of a drag-reducing polymer extracted from aloe vera prolonged survival time in a rat model of acute myocardial ischaemia† T. Sakai, B.M.

Evolution of cerebral ischaemia induced by thromboembolism in rats detected by early sequential MR imaging S. Ishikawa, K. Yokoyama, T. Kuroiwa, K. Makita

Comparative study of topical anaesthesia with lidocaine 2% vs levobupivacaine 0.75% in cataract surgery S.A. Fernández, E. Dios, J.C. Diz British Journal.

Emetic effects of morphine and piritramide†

Electrophysiological effects of morphine in an in vitro model of the ‘border zone’ between normal and ischaemic–reperfused guinea-pig myocardium A. Yvon,

Post-conditioning by a short administration of desflurane reduced renal reperfusion injury after differing of ischaemia times in rats D. Obal, K. Rascher,

S Singh, J.E. Smith British Journal of Anaesthesia

J.M. van Schalkwyk, D. Lowes, C. Frampton, A.F. Merry

Anaesthesia for awake craniotomy—evolution of a technique that facilitates awake neurological testing A. Sarang, J. Dinsmore British Journal of Anaesthesia

R.J. Roche, C. Mackinlay, A. McLaughlin, K. Panikkar, J.D. Young

Distraction and interruption in anaesthetic practice

Comparison of 1% and 2% lidocaine epidural anaesthesia combined with sevoflurane general anaesthesia utilizing a constant bispectral index A Shono, S.

J.G. Hardman, J.S. Wills British Journal of Anaesthesia

Real-time breath monitoring of propofol and its volatile metabolites during surgery using a novel mass spectrometric technique: a feasibility study G.R.

J.E. Heavner, A.D. Kaye, B.-K. Lin, T. King

D. Fu, P. Vissavajjhala, Hemmings H.C. British Journal of Anaesthesia

U. Eichenberger, C. Giani, S. Petersen-Felix, T. Graven-Nielsen, L

Roles of nociceptin/orphanin FQ and nociceptin/orphanin FQ peptide receptor in respiratory rhythm generation in the medulla oblongata: an in vitro study

Sevoflurane preconditioning-induced neuroprotection is associated with Akt activation via carboxy-terminal modulator protein inhibition Y. Chen, H. Nie,

Asynchronous administration of xenon and hypothermia significantly reduces brain infarction in the neonatal rat J.L. Martin, D. Ma, M. Hossain, J. Xu,

J.-L. Vincent, M.M. Wilkes, R.J. Navickis

Teamwork, communication, and anaesthetic assistance in Scotland

Cross-tolerance between spinal neostigmine and morphine in the rat

Small dose of clonidine mixed with low-dose ropivacaine and fentanyl for epidural analgesia after total knee arthroplasty† Förster J.G. , Rosenberg P.H.

J.G. Laffey, é. Tobin, J.F. Boylan, A.J. McShane

Adding lactate to the prime solution during hypothermic cardiopulmonary bypass: a quantitative acid–base analysis D. Himpe, H. Neels, S. De Hert, P.

Another case of obstruction to an anaesthetic circuit

D.A. Rowney, R. Fairgrieve, B. Bissonnette

Cardioprotection by sevoflurane against reperfusion injury after cardioplegic arrest in the rat is independent of three types of cardioplegia D. Ebel,

D. Obal, B. Preckel, H. Scharbatke, J. Müllenheim, F. Höterkes, V

Brain ischemic tolerance model using mouse MCAO

S. Singaravelu, P. Barclay British Journal of Anaesthesia

Adenosine and lidocaine: a new concept in nondepolarizing surgical myocardial arrest, protection, and preservation Geoffrey P. Dobson, PhD, Michael W.

Presentation transcript:

Desflurane affords greater protection than halothane against focal cerebral ischaemia in the rat B. Haelewyn, A. Yvon, J.L. Hanouz, E.T. MacKenzie, P. Ducouret, J.L. Gérard, S. Roussel British Journal of Anaesthesia Volume 91, Issue 3, Pages 390-396 (September 2003) DOI: 10.1093/bja/aeg186 Copyright © 2003 British Journal of Anaesthesia Terms and Conditions

Fig 1 Experimental protocol. The preparation of each animal lasted approximately 45 min. MCAo was maintained for 2 h, followed by reperfusion. The following day (24 h), infarcts were revealed by TTC staining. Four groups were studied which differed according to the anaesthetic drug used (halothane or desflurane) and the duration of anaesthesia, as shown. All anaesthetics were delivered in oxygen:nitrous oxide (30:70%). British Journal of Anaesthesia 2003 91, 390-396DOI: (10.1093/bja/aeg186) Copyright © 2003 British Journal of Anaesthesia Terms and Conditions

Fig 2 Typical TTC stained coronal section (striatum level) showing the extent of infarct. The section is 1 mm thick. The white area corresponds to the infarcted surface. Both striatum and cortex are lesioned. British Journal of Anaesthesia 2003 91, 390-396DOI: (10.1093/bja/aeg186) Copyright © 2003 British Journal of Anaesthesia Terms and Conditions

Fig 3 Infarct volumes (in mm3) in the four groups. *Significant difference between the two groups (Student's t-test following a two-way anova). Individual values in addition to mean (sd) are indicated. British Journal of Anaesthesia 2003 91, 390-396DOI: (10.1093/bja/aeg186) Copyright © 2003 British Journal of Anaesthesia Terms and Conditions

Fig 4 Time course of MAP changes in the four groups. Continuous MAP recordings were averaged over 20 min periods. Two-way anovas (duration, anaesthetic) were performed at each time period (following a three-way anova, see text for details). †Significant main effect of the anaesthetic factor. *Significant difference between short-duration halothane and short-duration desflurane groups. #Significant effect of the duration factor at each time period. British Journal of Anaesthesia 2003 91, 390-396DOI: (10.1093/bja/aeg186) Copyright © 2003 British Journal of Anaesthesia Terms and Conditions

Fig 5 Time course of pericranial temperature in long-duration halothane and long-duration desflurane groups (additional study). Continuous pericranial temperature recordings were averaged over 30 min periods. A two-way anova (anaesthetic, time) was performed and no difference was found between the groups (P>0.17). British Journal of Anaesthesia 2003 91, 390-396DOI: (10.1093/bja/aeg186) Copyright © 2003 British Journal of Anaesthesia Terms and Conditions