Low-level lead exposure and mortality in US adults: a population-based cohort study Prof Bruce P Lanphear, MD, Stephen Rauch, MPH, Peggy Auinger, MS,

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Presentation transcript:

Low-level lead exposure and mortality in US adults: a population-based cohort study Prof Bruce P Lanphear, MD, Stephen Rauch, MPH, Peggy Auinger, MS, Ryan W Allen, PhD, Prof Richard W Hornung, DrPH The Lancet Public Health Volume 3, Issue 4, Pages e177-e184 (April 2018) DOI: 10.1016/S2468-2667(18)30025-2 Copyright © 2018 The Authors. Published by Elsevier Ltd. This is an Open Access article under the CC BY-NC-ND 4.0 license Terms and Conditions

Figure 1 Dose-response curves for concentrations of lead in blood and mortality Adjusted hazard ratios (black lines) with 95% CIs (hatched lines) and restricted cubic spline (red lines) for (A) all-cause mortality, (B) cardiovascular disease mortality, and (C) ischaemic heart disease mortality. The Lancet Public Health 2018 3, e177-e184DOI: (10.1016/S2468-2667(18)30025-2) Copyright © 2018 The Authors. Published by Elsevier Ltd. This is an Open Access article under the CC BY-NC-ND 4.0 license Terms and Conditions

Figure 2 Risk factors for all-cause mortality, cardiovascular disease mortality, and ischaemic heart disease mortality Adjusted hazard ratios (HRs) are shown as dots and 95% CIs as horizontal lines. HRs for cholesterol and glycated haemoglobin (HbA1c) refer to an IQR-sized increase (56 mg/dL and 0·7%, respectively). HRs for age represent a 10-year increase. The Lancet Public Health 2018 3, e177-e184DOI: (10.1016/S2468-2667(18)30025-2) Copyright © 2018 The Authors. Published by Elsevier Ltd. This is an Open Access article under the CC BY-NC-ND 4.0 license Terms and Conditions

Figure 3 Attributable deaths associated with selected modifiable risk factors in the US population Panels show deaths from (A) all causes, (B) cardiovascular disease, and (C) ischaemic heart disease. Modifiable risk factors are presented in red and protective factors in blue. Deaths were calculated from population attributable fractions and average mortality in the USA from 1988 to 2011. Only significant risk factors are represented. The Lancet Public Health 2018 3, e177-e184DOI: (10.1016/S2468-2667(18)30025-2) Copyright © 2018 The Authors. Published by Elsevier Ltd. This is an Open Access article under the CC BY-NC-ND 4.0 license Terms and Conditions