Screening Drugs for Kidney Disease: Targeting the Podocyte

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Screening Drugs for Kidney Disease: Targeting the Podocyte Joshua S. Bryer, Katalin Susztak Cell Chemical Biology Volume 25, Issue 2, Pages 126-127 (February 2018) DOI: 10.1016/j.chembiol.2018.01.018 Copyright © 2018 Elsevier Ltd Terms and Conditions

Figure 1 Podocyte Loss Plays Key Role in Kidney Disease Development; CDG-0876 Protects from Podocyte Apoptosis (A) Schematic representation of the nephron and a healthy glomerulus. (B) Genetic and environmental alterations lead to podocyte injury, such as foot process effacement, that causes albuminuria. Severe podocyte injury is associated with podocyte apoptosis and death, resulting in scarring of the glomerulus and leading to kidney failure. CDG-0876 was able to protect from podocyte apoptosis. Cell Chemical Biology 2018 25, 126-127DOI: (10.1016/j.chembiol.2018.01.018) Copyright © 2018 Elsevier Ltd Terms and Conditions