Early rule-out and rule-in of myocardial infarction using sensitive cardiac Troponin I Sophie Druey, Karin Wildi, Raphael Twerenbold, Cédric Jaeger, Tobias.

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Early rule-out and rule-in of myocardial infarction using sensitive cardiac Troponin I Sophie Druey, Karin Wildi, Raphael Twerenbold, Cédric Jaeger, Tobias Reichlin, Philip Haaf, Maria Rubini Gimenez, Christian Puelacher, Max Wagener, Milos Radosavac, Ursina Honegger, Carmela Schumacher, Valentina Delfine, Philip Kreutzinger, Thomas Herrmann, Zoraida Moreno Weidmann, Lian Krivoshei, Michael Freese, Claudia Stelzig, Cyril Isenschmid, Stefano Bassetti, Katharina Rentsch, Stefan Osswald, Christian Mueller International Journal of Cardiology Volume 195, Pages 163-170 (September 2015) DOI: 10.1016/j.ijcard.2015.05.079 Copyright © 2015 The Authors Terms and Conditions

Fig. 1 Prevalence of acute myocardial infarction (AMI) according to absolute levels of sensitive cTnI at presentation and after one and two hours (h). Five categories are displayed, with four pre-defined level thresholds corresponding to the assay lower limit of detection of 6ng/L, 10ng/L (representing the optimal rule-out cutoff observed for the 1h- and 2h-algorithm), 40ng/L (as defined as the assay's 99th percentile) and 100ng/L (empirically selected). n=number of patients with AMI corresponding to categories. International Journal of Cardiology 2015 195, 163-170DOI: (10.1016/j.ijcard.2015.05.079) Copyright © 2015 The Authors Terms and Conditions

Fig. 2 1h-algorithm (A=derivation cohort, B=validation cohort) and 2h-algorithm (C=derivation cohort, D=validation cohort) for diagnosis of AMI using sensitive cTnI in patients presenting with acute chest pain. AMI: acute myocardial infarction, h=hour(s), NPV: negative predictive value, n=number, PPV: positive predictive value. International Journal of Cardiology 2015 195, 163-170DOI: (10.1016/j.ijcard.2015.05.079) Copyright © 2015 The Authors Terms and Conditions

Fig. 3 Kaplan Meier-curves for the cumulative all-cause mortality. (A) At 30-days and (B) at one year according to the classification provided by the sensitive cTnI 1h-algorithm in “rule-out”, “observe” and “rule-in”. ED=emergency department. International Journal of Cardiology 2015 195, 163-170DOI: (10.1016/j.ijcard.2015.05.079) Copyright © 2015 The Authors Terms and Conditions