Reproduction at an advanced maternal age and maternal health Mark V. Sauer, M.D.  Fertility and Sterility  Volume 103, Issue 5, Pages 1136-1143 (May 2015) DOI: 10.1016/j.fertnstert.2015.03.004 Copyright © 2015 American Society for Reproductive Medicine Terms and Conditions

Figure 1 Birth rates by selected age of the mother: United States, 1990–2012. Source: CDC/Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Vital Statistics System. Fertility and Sterility 2015 103, 1136-1143DOI: (10.1016/j.fertnstert.2015.03.004) Copyright © 2015 American Society for Reproductive Medicine Terms and Conditions

Figure 2 Change in the (A) total number of births and (B) birth rate among women aged 45 and older in the United States. From reference (12). Fertility and Sterility 2015 103, 1136-1143DOI: (10.1016/j.fertnstert.2015.03.004) Copyright © 2015 American Society for Reproductive Medicine Terms and Conditions

Figure 3 Prevalence of aneuploidy relative to age in (A) biopsied human preimplantation and (B) the percentage of cycles with no euploid embryos on biopsy. Reproduced with permission from Franasiak et al. (12). Fertility and Sterility 2015 103, 1136-1143DOI: (10.1016/j.fertnstert.2015.03.004) Copyright © 2015 American Society for Reproductive Medicine Terms and Conditions

Figure 4 Maternal mortality rates by age in the United States as reported to the CDC and Prevention 2005. Source: US Department of Health and Human Services, Health Resources and Services Administration, Maternal and Child health Bureau. Women's Health USA 2008. Fertility and Sterility 2015 103, 1136-1143DOI: (10.1016/j.fertnstert.2015.03.004) Copyright © 2015 American Society for Reproductive Medicine Terms and Conditions